qqman
The Manhattan-plot package for GWAS results, finished and dormant since 2017.
Comparison · Analytics
tern.mmrm vs TwoSampleMR
A side-by-side editorial comparison of tern.mmrm and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
tern.mmrm vs TwoSampleMR: at a glance
What is tern.mmrm?
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
tern.mmrm wraps mixed models for repeated measures into the tern tabulation and plotting layer used by teal clinical modules. The visible history ends with three CRAN releases in mid-to-late 2024; before that the feed carries only automated version bumps from 2022, three of which have just been backfilled into the record. The most recent substantive change adds axis limit arguments to the LS-means plot.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
tern.mmrm vs TwoSampleMR: editorial side-by-side
tern.mmrm
0.0ANALYTICS
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
◆ Current state
tern.mmrm wraps mixed models for repeated measures into the tern tabulation and plotting layer used by teal clinical modules. The visible history ends with three CRAN releases in mid-to-late 2024; before that the feed carries only automated version bumps from 2022, three of which have just been backfilled into the record. The most recent substantive change adds axis limit arguments to the LS-means plot.
◆ Where it's heading
Content per release is thin and largely organisational: a maintainer change, replacing scda with random.cdisc.data in vignettes, and adapting to new {mmrm} versions. The package appears to be in maintenance, tracking its upstream dependency rather than developing independently. The 2022 entries now visible are release-automation commits, not releases in any meaningful sense.
◆ Prediction
Nothing here signals new functionality; the realistic next event is another compatibility release when {mmrm} or {rtables} changes underneath it.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to tern.mmrm and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either tern.mmrm or TwoSampleMR.
constants
The R package for CODATA constants rebuilt its symbol table on NIST's naming so future updates stop being hand work.
austraits
The R client for AusTraits spends its releases chasing the dataset it reads.
ggdemetra
A ggplot2 layer for seasonal adjustment output, filling in one plot type at a time.
fossilsim
A fossil-record simulator that quietly grew a trait-evolution engine.
tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
See all tern.mmrm alternatives → · See all TwoSampleMR alternatives →
Recent activity from tern.mmrm and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agotern.mmrmAxis limits added to the LS-means plot
- 2y agotern.mmrmMaintainer change and scda replaced in vignettes
- 2y agotern.mmrmCRAN 0.3.0 release, mostly workflow housekeeping
- 3y agotern.mmrmAutomated version bump to 0.2.1
- 3y agotern.mmrmPre-release branch merge
- 4y agotern.mmrmCI automation commit, no release content
Frequently asked questions
What is the difference between tern.mmrm and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. tern.mmrm and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is tern.mmrm better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. tern.mmrm and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to tern.mmrm?
Top tern.mmrm alternatives in Analytics are ranked by recent ship velocity. Browse the "tern.mmrm alternatives" section above for the current picks, or visit /alternatives/tern-mmrm for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.