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qqman vs TwoSampleMR

A side-by-side editorial comparison of qqman and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.

qqman vs TwoSampleMR: at a glance

FeatureqqmanTwoSampleMR
SectorAnalyticsAnalytics
Velocity score0.00.0
Sparks · 30d00
Top themesgwas, genomics, manhattan-plot, visualizationmendelian-randomization, genetic-epidemiology, correctness-fixes, opengwas
Last editorial update1h ago9h ago
WebsiteVisit →Visit →

What is qqman?

The Manhattan-plot package for GWAS results, finished and dormant since 2017.

qqman does two things: manhattan() and qq() plots for genome-wide association study results. Its six visible releases run from 2014 to a single 2017 packaging fix, and the last release with any user-facing change shipped in 2015. The archive is non-monotonic — a 0.0.0 tag published after 0.1.1 archives the pre-package standalone script — so version order and publication order disagree.

Read the full qqman trajectory →

What is TwoSampleMR?

The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.

TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.

Read the full TwoSampleMR trajectory →

qqman vs TwoSampleMR: editorial side-by-side

Q
qqman
ANALYTICS
0.0

The Manhattan-plot package for GWAS results, finished and dormant since 2017.

◆ Current state

qqman does two things: manhattan() and qq() plots for genome-wide association study results. Its six visible releases run from 2014 to a single 2017 packaging fix, and the last release with any user-facing change shipped in 2015. The archive is non-monotonic — a 0.0.0 tag published after 0.1.1 archives the pre-package standalone script — so version order and publication order disagree.

◆ Where it's heading

The real development window was 2014 to 2015. The 0.1.2 release did the substantive work, replacing the assumption that SNPs are evenly distributed across chromosomes and handing users control of axis limits, labels and log transformation; 0.1.3 then added annotation by p-value threshold and top-SNP-per-chromosome. After that the package stops. Notably, the archival 0.0.0 entry records that the original script had confidence intervals on QQ plots and richer highlighting than the released package ever regained.

◆ Prediction

With one packaging fix in the last decade, these entries support no prediction of further releases. The package reads as complete for its narrow purpose rather than abandoned mid-arc.

T
TwoSampleMR
ANALYTICS
0.0

The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.

◆ Current state

TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.

◆ Where it's heading

The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.

◆ Prediction

Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.

Alternatives to qqman and TwoSampleMR

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either qqman or TwoSampleMR.

See all qqman alternatives → · See all TwoSampleMR alternatives →

Recent activity from qqman and TwoSampleMR

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
  2. 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
  3. 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
  4. 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
  5. 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
  6. 4mo agoTwoSampleMRFurther internal code optimizations
  7. 9y agoqqmanREADME image path fix for pandoc
  8. 11y agoqqmanAnnotate SNPs by p-value threshold or per-chromosome top hit
  9. 11y agoqqmanChromosome ticks stop assuming even SNP spacing; axis control opens up
  10. 12y agoqqmanArchival tag for the pre-package standalone script
  11. 12y agoqqmanVignette touch-up
  12. 12y agoqqmanZenodo archival tag, no code change

Frequently asked questions

What is the difference between qqman and TwoSampleMR?

They serve adjacent needs but don't currently overlap on shipped themes. qqman and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is qqman better than TwoSampleMR?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. qqman and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to qqman?

Top qqman alternatives in Analytics are ranked by recent ship velocity. Browse the "qqman alternatives" section above for the current picks, or visit /alternatives/qqman-r for the full list with editorial commentary on each.

What are the best alternatives to TwoSampleMR?

Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.