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tern.rbmi vs TwoSampleMR

A side-by-side editorial comparison of tern.rbmi and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.

tern.rbmi vs TwoSampleMR: at a glance

Featuretern.rbmiTwoSampleMR
SectorAnalyticsAnalytics
Velocity score0.00.0
Sparks · 30d00
Top themespharmaverse, multiple-imputation, cran-maintenance, tabulationmendelian-randomization, genetic-epidemiology, correctness-fixes, opengwas
Last editorial update1h ago8h ago
WebsiteVisit →Visit →

What is tern.rbmi?

Reference-based multiple imputation tables, shipping only what CRAN checks demand.

tern.rbmi renders the output of {rbmi} reference-based multiple imputation analyses into tern tables for clinical reporting. Its three most recent releases exist to satisfy CRAN: restricting vignette builds to gcc, adding V8 to Suggests, and a plain resubmission. No user-facing functionality has changed in the visible window, and the three older entries now backfilled are version-bump automation.

Read the full tern.rbmi trajectory →

What is TwoSampleMR?

The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.

TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.

Read the full TwoSampleMR trajectory →

tern.rbmi vs TwoSampleMR: editorial side-by-side

T
tern.rbmi
ANALYTICS
0.0

Reference-based multiple imputation tables, shipping only what CRAN checks demand.

◆ Current state

tern.rbmi renders the output of {rbmi} reference-based multiple imputation analyses into tern tables for clinical reporting. Its three most recent releases exist to satisfy CRAN: restricting vignette builds to gcc, adding V8 to Suggests, and a plain resubmission. No user-facing functionality has changed in the visible window, and the three older entries now backfilled are version-bump automation.

◆ Where it's heading

This is a thin adapter package and behaves like one — it moves when CRAN or an upstream dependency forces it to. Between 2022 and 2024 the feed shows only version bumps, and the 2025 releases are packaging concerns rather than analysis changes. The newly surfaced 2022 entries reinforce rather than change that reading.

◆ Prediction

Expect the next release to be triggered by a CRAN check failure or an {rbmi} update rather than by new tabulation features.

T
TwoSampleMR
ANALYTICS
0.0

The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.

◆ Current state

TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.

◆ Where it's heading

The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.

◆ Prediction

Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.

Alternatives to tern.rbmi and TwoSampleMR

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either tern.rbmi or TwoSampleMR.

See all tern.rbmi alternatives → · See all TwoSampleMR alternatives →

Recent activity from tern.rbmi and TwoSampleMR

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
  2. 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
  3. 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
  4. 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
  5. 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
  6. 4mo agoTwoSampleMRFurther internal code optimizations
  7. 1y agotern.rbmiVignette built only under gcc
  8. 1y agotern.rbmiV8 added to Suggests
  9. 1y agotern.rbmiCRAN resubmission with dependency and workflow updates
  10. 3y agotern.rbmiAutomated release commit for 0.1.1
  11. 4y agotern.rbmiDevelopment version bump to 0.1.0.9004
  12. 4y agotern.rbmiCI automation commit, no release content

Frequently asked questions

What is the difference between tern.rbmi and TwoSampleMR?

They serve adjacent needs but don't currently overlap on shipped themes. tern.rbmi and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is tern.rbmi better than TwoSampleMR?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. tern.rbmi and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to tern.rbmi?

Top tern.rbmi alternatives in Analytics are ranked by recent ship velocity. Browse the "tern.rbmi alternatives" section above for the current picks, or visit /alternatives/tern-rbmi for the full list with editorial commentary on each.

What are the best alternatives to TwoSampleMR?

Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.