qqman
The Manhattan-plot package for GWAS results, finished and dormant since 2017.
Comparison · Analytics
fossilsim vs TwoSampleMR
A side-by-side editorial comparison of fossilsim and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
fossilsim vs TwoSampleMR: at a glance
What is fossilsim?
A fossil-record simulator that quietly grew a trait-evolution engine.
FossilSim is a mature R package for simulating fossil records on phylogenetic trees, and its release cadence reflects that: long gaps punctuated by a single capability addition. The last four releases span three years, with the most recent being a compatibility sync to its companion Shiny front-end rather than new functionality. The core simulation surface has been stable since 2022.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
fossilsim vs TwoSampleMR: editorial side-by-side
fossilsim
0.0ANALYTICS
A fossil-record simulator that quietly grew a trait-evolution engine.
◆ Current state
FossilSim is a mature R package for simulating fossil records on phylogenetic trees, and its release cadence reflects that: long gaps punctuated by a single capability addition. The last four releases span three years, with the most recent being a compatibility sync to its companion Shiny front-end rather than new functionality. The core simulation surface has been stable since 2022.
◆ Where it's heading
The arc runs from sampling mechanics toward simulating what the organisms actually were. Version 2.2.0 taught the package to handle occurrence data for occurrence birth-death models; 2.3.0 then added trait simulation under Mk, BM and OU, which is a different kind of output than fossil ages. Since then the work has been maintenance and keeping the FossilSimShiny GUI in step, suggesting the authors consider the current model set feature-complete.
◆ Prediction
The pairing of the 2.3.3 release with a FossilSimShiny version bump points to the GUI, not the library, as where the next visible work lands. The entries do not show enough activity to predict a specific new model family.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to fossilsim and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either fossilsim or TwoSampleMR.
constants
The R package for CODATA constants rebuilt its symbol table on NIST's naming so future updates stop being hand work.
austraits
The R client for AusTraits spends its releases chasing the dataset it reads.
ggdemetra
A ggplot2 layer for seasonal adjustment output, filling in one plot type at a time.
tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
tern.mmrm
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
See all fossilsim alternatives → · See all TwoSampleMR alternatives →
Recent activity from fossilsim and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 2y agofossilsimCompatibility bump for FossilSimShiny 1.1.2
- 4y agofossilsimBug fixes and documentation cleanup
- 4y agofossilsimTrait simulation arrives: Mk, BM and OU models ⚡
- 5y agofossilsimOccurrence handling for the occurrence birth-death model
Frequently asked questions
What is the difference between fossilsim and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. fossilsim and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is fossilsim better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. fossilsim and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to fossilsim?
Top fossilsim alternatives in Analytics are ranked by recent ship velocity. Browse the "fossilsim alternatives" section above for the current picks, or visit /alternatives/fossilsim-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.