qqman
The Manhattan-plot package for GWAS results, finished and dormant since 2017.
Comparison · Analytics
gtfstools vs TwoSampleMR
A side-by-side editorial comparison of gtfstools and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
gtfstools vs TwoSampleMR: at a glance
What is gtfstools?
gtfstools stopped guarding its own object model and started accepting everyone else's.
gtfstools reads, edits, filters and validates GTFS public transport feeds in R on a data.table backend. Since 1.3.0 it accepts GTFS objects produced by other packages such as gtfsio and tidytransit, converting them through an as_dt_gtfs() generic. Validation runs MobilityData's canonical validator, now supported through v6.0.0.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
gtfstools vs TwoSampleMR: editorial side-by-side
gtfstools
0.0ANALYTICS
gtfstools stopped guarding its own object model and started accepting everyone else's.
◆ Current state
gtfstools reads, edits, filters and validates GTFS public transport feeds in R on a data.table backend. Since 1.3.0 it accepts GTFS objects produced by other packages such as gtfsio and tidytransit, converting them through an as_dt_gtfs() generic. Validation runs MobilityData's canonical validator, now supported through v6.0.0.
◆ Where it's heading
The package built out a wide function surface first — filters, geometry conversion, speed and duration calculations — then turned outward. Delegating validation to MobilityData's validator and accepting other packages' objects both trade self-sufficiency for a position inside the wider GTFS ecosystem. Deprecations are handled slowly, with old behaviour left as the default for a release or more.
◆ Prediction
Expect continued validator version tracking and further completion of the deprecation cycle around filter_by_stop_id()'s full_trips behaviour.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to gtfstools and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either gtfstools or TwoSampleMR.
constants
The R package for CODATA constants rebuilt its symbol table on NIST's naming so future updates stop being hand work.
austraits
The R client for AusTraits spends its releases chasing the dataset it reads.
ggdemetra
A ggplot2 layer for seasonal adjustment output, filling in one plot type at a time.
fossilsim
A fossil-record simulator that quietly grew a trait-evolution engine.
tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
See all gtfstools alternatives → · See all TwoSampleMR alternatives →
Recent activity from gtfstools and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agogtfstoolsSupports canonical GTFS validator v5 and v6
- 1y agogtfstoolsAccepts GTFS objects from gtfsio and tidytransit ⚡
- 3y agogtfstoolsValidation delegated to MobilityData's canonical validator
- 4y agogtfstoolsAdds time-of-day, weekday and frequency filtering functions
- 4y agogtfstoolsEstablishes the core GTFS filtering and sf conversion family
Frequently asked questions
What is the difference between gtfstools and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. gtfstools and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is gtfstools better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. gtfstools and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to gtfstools?
Top gtfstools alternatives in Analytics are ranked by recent ship velocity. Browse the "gtfstools alternatives" section above for the current picks, or visit /alternatives/gtfstools-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.