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Comparison · Analytics
parallelDist vs TwoSampleMR
A side-by-side editorial comparison of parallelDist and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
parallelDist vs TwoSampleMR: at a glance
What is parallelDist?
parallelDist is in pure preservation mode — one build fix every few years.
parallelDist computes distance matrices across threads in C++ via RcppParallel and Armadillo. The feature set has been settled since 0.2.3 in 2018, which added hamming distance and cosine similarity; everything after that is compatibility work. The most recent release, 0.2.7, exists only to drop a C++11 pin that newer Armadillo versions no longer tolerate.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
parallelDist vs TwoSampleMR: editorial side-by-side
parallelDist
0.0ANALYTICS
parallelDist is in pure preservation mode — one build fix every few years.
◆ Current state
parallelDist computes distance matrices across threads in C++ via RcppParallel and Armadillo. The feature set has been settled since 0.2.3 in 2018, which added hamming distance and cosine similarity; everything after that is compatibility work. The most recent release, 0.2.7, exists only to drop a C++11 pin that newer Armadillo versions no longer tolerate.
◆ Where it's heading
The package is being kept installable, not developed. The three most recent releases are a toolchain pin removal, a DESCRIPTION field removal, and a coercion change inherited from proxy — none originate from user-facing intent. Gaps of three to four years between releases are the norm now, and each one is triggered by something upstream breaking rather than by a roadmap.
◆ Prediction
The next release will almost certainly be another compatibility fix timed to whatever Armadillo, Rcpp or CRAN check policy changes next. Nothing in the entries points to new distance measures or API work.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to parallelDist and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either parallelDist or TwoSampleMR.
geodist
geodist stays dependency-free and fast, and warns you when 'cheap' distances stop being honest.
errors
errors keeps making uncertainty print the way each scientific field expects.
CMAQ
CMAQ went global in v5.5, and has been patching that surface ever since.
enpls
enpls has not changed its statistics since 2016 — only its website, twice.
grex
grex is a lookup table with a version number — it ships when the annotation moves.
See all parallelDist alternatives → · See all TwoSampleMR alternatives →
Recent activity from parallelDist and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 10mo agoparallelDistparallelDist 0.2.7 drops the C++11 pin for newer Armadillo
- 4y agoparallelDistparallelDist 0.2.6: LazyData removed, vignette font swapped
- 4y agoparallelDistparallelDist 0.2.5 changes cosine distance to 1-x
- 7y agoparallelDistparallelDist 0.2.4 fixes the Solaris build
- 7y agoparallelDistparallelDist 0.2.3 adds hamming and cosine measures
- 7y agoparallelDistparallelDist 0.2.2
Frequently asked questions
What is the difference between parallelDist and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. parallelDist and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is parallelDist better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. parallelDist and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to parallelDist?
Top parallelDist alternatives in Analytics are ranked by recent ship velocity. Browse the "parallelDist alternatives" section above for the current picks, or visit /alternatives/paralleldist for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.