tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
Comparison · Analytics
grex vs TwoSampleMR
A side-by-side editorial comparison of grex and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
grex vs TwoSampleMR: at a glance
What is grex?
grex is a lookup table with a version number — it ships when the annotation moves.
grex converts the deprecated Ensembl gene IDs found in GTEx data into current gene symbols and identifiers, using org.Hs.eg.db as its reference. Its value is entirely in that bundled reference data, so a release either refreshes the mapping or does nothing to it. The 2025 release does nothing to it: GitHub Actions for the docs site, a check-note fix, and a smaller vignette.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
grex vs TwoSampleMR: editorial side-by-side
grex
0.0ANALYTICS
grex is a lookup table with a version number — it ships when the annotation moves.
◆ Current state
grex converts the deprecated Ensembl gene IDs found in GTEx data into current gene symbols and identifiers, using org.Hs.eg.db as its reference. Its value is entirely in that bundled reference data, so a release either refreshes the mapping or does nothing to it. The 2025 release does nothing to it: GitHub Actions for the docs site, a check-note fix, and a smaller vignette.
◆ Where it's heading
The annotation refreshes stopped. Between 2017 and 2019 the package tracked org.Hs.eg.db through four versions and added the GTEx V7 identifier set; since then the reference has stood still while the releases turned to packaging. That gap matters more here than it would elsewhere — a stale mapping table silently returns outdated symbols rather than failing, so the package's core asset ages invisibly.
◆ Prediction
Nothing in these entries signals a planned data refresh, and the six-year pattern suggests the next release will again be infrastructure. Users needing current annotations should check which org.Hs.eg.db version is bundled rather than assume the version number reflects it.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to grex and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either grex or TwoSampleMR.
tern.mmrm
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
ggmagnify
A single-purpose ggplot2 inset tool, refining the same three arguments.
symengine
An R symbolic-maths binding whose changelog is really the C++ core's release notes.
gtfstools
gtfstools stopped guarding its own object model and started accepting everyone else's.
quantities
The glue package that makes R carry units and uncertainty through the same calculation.
See all grex alternatives → · See all TwoSampleMR alternatives →
Recent activity from grex and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agogrexgrex 1.9.1: pkgdown on Actions, smaller vignette
- 7y agogrexgrex 1.9 refreshes the reference to org.Hs.eg.db 3.8.2
- 8y agogrexgrex 1.8 adds GTEx V7 IDs, updates to org.Hs.eg.db 3.6.0
- 8y agogrexgrex 1.7 updates the reference to org.Hs.eg.db 3.4.2
- 8y agogrexgrex 1.6 drops Google Fonts from vignettes
- 9y agogrexgrex 1.5 adds a pkgdown site and refreshes the reference
Frequently asked questions
What is the difference between grex and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. grex and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is grex better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. grex and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to grex?
Top grex alternatives in Analytics are ranked by recent ship velocity. Browse the "grex alternatives" section above for the current picks, or visit /alternatives/grex-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.