tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
Comparison · Analytics
enpls vs TwoSampleMR
A side-by-side editorial comparison of enpls and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
enpls vs TwoSampleMR: at a glance
What is enpls?
enpls has not changed its statistics since 2016 — only its website, twice.
enpls implements ensemble partial least squares regression, with variants for feature selection, outlier detection and model applicability. Across the six most recent releases there is not one change to the modeling code. They cover a documentation website, a website URL change, a font stack, code indentation, a CI service, and most recently a GitHub Actions migration with an R CMD check note fix.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
enpls vs TwoSampleMR: editorial side-by-side
enpls
0.0ANALYTICS
enpls has not changed its statistics since 2016 — only its website, twice.
◆ Current state
enpls implements ensemble partial least squares regression, with variants for feature selection, outlier detection and model applicability. Across the six most recent releases there is not one change to the modeling code. They cover a documentation website, a website URL change, a font stack, code indentation, a CI service, and most recently a GitHub Actions migration with an R CMD check note fix.
◆ Where it's heading
The statistical work finished around version 5.6, which added cross-validation fold control and fixed component selection when the maximum was left unspecified. Everything since has kept the package installable and its docs online. The 2025 release arriving the same day as sibling package grex, with the same two fixes, confirms the pattern: these are maintainer sweeps across a portfolio, not attention to enpls specifically.
◆ Prediction
The next release will almost certainly be another CRAN or tooling fix. Six consecutive infrastructure-only releases across nine years give no basis for expecting new methods.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to enpls and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either enpls or TwoSampleMR.
tern.mmrm
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
ggmagnify
A single-purpose ggplot2 inset tool, refining the same three arguments.
symengine
An R symbolic-maths binding whose changelog is really the C++ core's release notes.
gtfstools
gtfstools stopped guarding its own object model and started accepting everyone else's.
quantities
The glue package that makes R carry units and uncertainty through the same calculation.
See all enpls alternatives → · See all TwoSampleMR alternatives →
Recent activity from enpls and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agoenplsenpls 6.1.1 moves pkgdown to GitHub Actions
- 7y agoenplsenpls 6.1 adopts tidyverse code style
- 8y agoenplsenpls 6.0 changes the documentation URL
- 8y agoenplsenpls 5.9 drops Google Fonts from vignettes
- 9y agoenplsenpls 5.8 updates gallery images, enables HTTPS
- 9y agoenplsenpls 5.7 adds a pkgdown site and Windows CI
Frequently asked questions
What is the difference between enpls and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. enpls and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is enpls better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. enpls and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to enpls?
Top enpls alternatives in Analytics are ranked by recent ship velocity. Browse the "enpls alternatives" section above for the current picks, or visit /alternatives/enpls for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.