tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
Comparison · Analytics
paleobuddy vs TwoSampleMR
A side-by-side editorial comparison of paleobuddy and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
paleobuddy vs TwoSampleMR: at a glance
What is paleobuddy?
paleobuddy can now simulate trait-dependent diversification, not just birth-death.
paleobuddy simulates diversification, fossil records and phylogenetic trees, with rates that can be arbitrary functions of time — its founding idea, implemented through rexp.var() generalizing exponential and Weibull draws. The 1.1.0 release adds state-dependent speciation and extinction simulation at roughly MuHiSSE generality, and lets simulations stop at a target number of extant species instead of conditioning on time.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
paleobuddy vs TwoSampleMR: editorial side-by-side
paleobuddy
0.0ANALYTICS
paleobuddy can now simulate trait-dependent diversification, not just birth-death.
◆ Current state
paleobuddy simulates diversification, fossil records and phylogenetic trees, with rates that can be arbitrary functions of time — its founding idea, implemented through rexp.var() generalizing exponential and Weibull draws. The 1.1.0 release adds state-dependent speciation and extinction simulation at roughly MuHiSSE generality, and lets simulations stop at a target number of extant species instead of conditioning on time.
◆ Where it's heading
Releases track the maintainer's publications rather than a product cadence — 1.0.0 accompanied the MEE manuscript, 1.0.0.1 exists purely as a Zenodo citation anchor, and 1.1.0 is stated as going with a paper on SSE model accuracy for trees including fossil data. That framing sets the direction: the package grows whichever capability the next study needs to test. The stated SSE limits, no quantitative traits and no cladogenetic transitions, mark exactly where that boundary currently sits.
◆ Prediction
Quantitative traits and cladogenetic transitions are named as missing, which makes them the obvious next targets, though on this history the timing will follow a paper rather than a roadmap.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to paleobuddy and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either paleobuddy or TwoSampleMR.
tern.mmrm
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
ggmagnify
A single-purpose ggplot2 inset tool, refining the same three arguments.
symengine
An R symbolic-maths binding whose changelog is really the C++ core's release notes.
gtfstools
gtfstools stopped guarding its own object model and started accepting everyone else's.
quantities
The glue package that makes R carry units and uncertainty through the same calculation.
See all paleobuddy alternatives → · See all TwoSampleMR alternatives →
Recent activity from paleobuddy and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agopaleobuddypaleobuddy 1.1.0 adds SSE trait-dependent simulation ⚡
- 3y agopaleobuddypaleobuddy 1.0.0.1: Zenodo citation release
- 4y agopaleobuddypaleobuddy 1.0.0: first release with time-varying rates
Frequently asked questions
What is the difference between paleobuddy and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. paleobuddy and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is paleobuddy better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. paleobuddy and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to paleobuddy?
Top paleobuddy alternatives in Analytics are ranked by recent ship velocity. Browse the "paleobuddy alternatives" section above for the current picks, or visit /alternatives/paleobuddy for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.