tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
Comparison · Analytics
CMAQ vs TwoSampleMR
A side-by-side editorial comparison of CMAQ and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
CMAQ vs TwoSampleMR: at a glance
What is CMAQ?
CMAQ went global in v5.5, and has been patching that surface ever since.
CMAQ is the EPA's Community Multiscale Air Quality modeling system, used for regulatory and research air quality simulation. Its release rhythm is strictly two-tier: numbered major versions carry new science and fresh benchmark datasets, while the x.y.z.n updates carry bug fixes against documentation and benchmarks that stay pinned to the parent version. The current line is v5.5, which introduced CRACMM2 chemistry and coupling to MPAS-A meteorology, followed by three patch rollups.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
CMAQ vs TwoSampleMR: editorial side-by-side
CMAQ
0.0ANALYTICS
CMAQ went global in v5.5, and has been patching that surface ever since.
◆ Current state
CMAQ is the EPA's Community Multiscale Air Quality modeling system, used for regulatory and research air quality simulation. Its release rhythm is strictly two-tier: numbered major versions carry new science and fresh benchmark datasets, while the x.y.z.n updates carry bug fixes against documentation and benchmarks that stay pinned to the parent version. The current line is v5.5, which introduced CRACMM2 chemistry and coupling to MPAS-A meteorology, followed by three patch rollups.
◆ Where it's heading
The v5.5 patches cluster around the newest and most sensitive components. ISAM source apportionment and DDM-3D sensitivity analysis account for corrections in every one of the three updates, and CRACMM2 needed fixes within months of release. That is the expected shape after a major version lands: the science is stable, the instrumentation built on top of it is not. Parallel I/O work in the latest patch suggests the global configurations are now being run at scales that expose throughput limits.
◆ Prediction
The next major version will fold these fixes in with new science, documentation and benchmark data — the release notes state this explicitly each time. Until then, expect further ISAM and DDM-3D corrections, which have appeared in every patch so far.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to CMAQ and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either CMAQ or TwoSampleMR.
tern.mmrm
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
ggmagnify
A single-purpose ggplot2 inset tool, refining the same three arguments.
symengine
An R symbolic-maths binding whose changelog is really the C++ core's release notes.
gtfstools
gtfstools stopped guarding its own object model and started accepting everyone else's.
quantities
The glue package that makes R carry units and uncertainty through the same calculation.
See all CMAQ alternatives → · See all TwoSampleMR alternatives →
Recent activity from CMAQ and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agoCMAQCMAQ 5.5.0.3 enables parallel I/O, fixes DDM-3D control files
- 1y agoCMAQCMAQ 5.5.0.2 corrects ISAM aerosol and cloud processing
- 1y agoCMAQCMAQ 5.5.0.1 fixes SAPRC mechanism runs and NLCD mapping
- 1y agoCMAQCMAQ 5.5 adds global simulation coupled to MPAS-A ⚡
- 1y agoCMAQCMAQ 5.4.0.5: minor ELMO output fixes
- 2y agoCMAQCMAQ 5.4.0.4 fixes RBSTATS under ROS3, corrects a molecular weight
Frequently asked questions
What is the difference between CMAQ and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. CMAQ and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is CMAQ better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. CMAQ and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to CMAQ?
Top CMAQ alternatives in Analytics are ranked by recent ship velocity. Browse the "CMAQ alternatives" section above for the current picks, or visit /alternatives/cmaq for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.