tern.rbmi
Reference-based multiple imputation tables, shipping only what CRAN checks demand.
Comparison · Analytics
gwasvcf vs protr
A side-by-side editorial comparison of gwasvcf and protr — release velocity, themes, recent moves, and the top alternatives to consider.
gwasvcf vs protr: at a glance
What is gwasvcf?
gwasvcf has stopped adding features and now just keeps proxy matching from failing.
gwasvcf reads and queries GWAS summary statistics stored as VCF, with LD proxy lookup as its most-used entry point. Every release in the visible window is a fix, and all but one land in or around proxy_match(). The last functional addition was gwasvcf_to_summaryset() in 0.1.2, which hands data to gwasglue2 rather than doing new work here.
What is protr?
protr's feature set is finished; the work now is surviving Bioconductor's churn.
protr generates numerical descriptors from protein sequences for machine learning, plus alignment-based similarity between sequences. The descriptor functions have been stable for years. Recent releases divide cleanly into two kinds: extending the similarity computations to work under memory constraints, and absorbing the Bioconductor split that moved pairwise alignment out of Biostrings into pwalign.
gwasvcf vs protr: editorial side-by-side
gwasvcf
0.0ANALYTICS
gwasvcf has stopped adding features and now just keeps proxy matching from failing.
◆ Current state
gwasvcf reads and queries GWAS summary statistics stored as VCF, with LD proxy lookup as its most-used entry point. Every release in the visible window is a fix, and all but one land in or around proxy_match(). The last functional addition was gwasvcf_to_summaryset() in 0.1.2, which hands data to gwasglue2 rather than doing new work here.
◆ Where it's heading
The package is in custodial maintenance inside the MRC IEU OpenGWAS stack, and its releases are reactive: each one answers a specific user-reported failure, credited to the reporter. The 0.1.6 pattern is telling — rather than replace the proxy VCF construction, it keeps the original path and adds a fallback only for inputs that fail, so existing results are left bit-for-bit unchanged.
◆ Prediction
Expect further narrow robustness fixes to proxy_match() driven by user-reported VCF shapes; nothing in the entries suggests new analysis capability is being built here rather than in gwasglue2.
protr
0.0ANALYTICS
protr's feature set is finished; the work now is surviving Bioconductor's churn.
◆ Current state
protr generates numerical descriptors from protein sequences for machine learning, plus alignment-based similarity between sequences. The descriptor functions have been stable for years. Recent releases divide cleanly into two kinds: extending the similarity computations to work under memory constraints, and absorbing the Bioconductor split that moved pairwise alignment out of Biostrings into pwalign.
◆ Where it's heading
The similarity side is where the remaining engineering goes, and it follows a consistent pattern — whatever parSeqSim() gained, crossSetSim() eventually gets. Batching, verbose progress and a disk-backed variant all arrived for the single-set case first and were mirrored for the cross-set case in 1.7-1. That is a maintainer closing feature-parity gaps rather than opening new directions, and the two most recent releases contain no user-facing change at all.
◆ Prediction
Expect the next release to react to another Bioconductor or R CMD check change, which accounts for three of the last four. The similarity functions now have parity, so there is no obvious internal backlog left.
Alternatives to gwasvcf and protr
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either gwasvcf or protr.
tern.mmrm
An MMRM tabulation package that has published nothing since its 2024 CRAN releases.
ggmagnify
A single-purpose ggplot2 inset tool, refining the same three arguments.
symengine
An R symbolic-maths binding whose changelog is really the C++ core's release notes.
gtfstools
gtfstools stopped guarding its own object model and started accepting everyone else's.
quantities
The glue package that makes R carry units and uncertainty through the same calculation.
See all gwasvcf alternatives → · See all protr alternatives →
Recent activity from gwasvcf and protr
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 5mo agogwasvcfproxy_match() gains a fallback VCF construction path
- 8mo agogwasvcfproxy_match() handles multi-sample VCFs
- 11mo agoprotrprotr 1.7-5 silences a Debian r-devel check note
- 1y agogwasvcfsqlite3 declared in SystemRequirements
- 1y agogwasvcfMessage fix in get_ld_proxies()
- 1y agoprotrprotr 1.7-4 checks alignment dependencies upfront
- 1y agoprotrprotr 1.7-3 detects Biostrings version to find pwalign
- 2y agoprotrprotr 1.7-2 fixes citation key and vignette accessibility
- 2y agoprotrprotr 1.7-1 brings crossSetSim to parity with parSeqSim
- 2y agoprotrprotr 1.7-0 adds crossSetSim for two-set similarity
- 2y agogwasvcfgwasvcf_to_summaryset() bridges to gwasglue2
Frequently asked questions
What is the difference between gwasvcf and protr?
They serve adjacent needs but don't currently overlap on shipped themes. gwasvcf and protr are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is gwasvcf better than protr?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. gwasvcf and protr are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to gwasvcf?
Top gwasvcf alternatives in Analytics are ranked by recent ship velocity. Browse the "gwasvcf alternatives" section above for the current picks, or visit /alternatives/gwasvcf for the full list with editorial commentary on each.
What are the best alternatives to protr?
Top protr alternatives in Analytics are ranked by recent ship velocity. Browse the "protr alternatives" section above for the current picks, or visit /alternatives/protr-r for the full list with editorial commentary on each.