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Comparison · Analytics
cairo vs TwoSampleMR
A side-by-side editorial comparison of cairo and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
cairo vs TwoSampleMR: at a glance
What is cairo?
Cairo finally catches R's graphics engine, all the way to GE API 16.
Cairo is the R device that renders plots through the cairo library, and until 1.7-0 it lagged R's own graphics engine by several API generations. That release closes the gap to GE API 16 (R 4.5.0), adding fill patterns, masks and groups. The releases before it were maintenance: a segfault shim for grid, a bashism removal in configure, and Windows font and build fixes.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
cairo vs TwoSampleMR: editorial side-by-side
cairo
0.0ANALYTICS
Cairo finally catches R's graphics engine, all the way to GE API 16.
◆ Current state
Cairo is the R device that renders plots through the cairo library, and until 1.7-0 it lagged R's own graphics engine by several API generations. That release closes the gap to GE API 16 (R 4.5.0), adding fill patterns, masks and groups. The releases before it were maintenance: a segfault shim for grid, a bashism removal in configure, and Windows font and build fixes.
◆ Where it's heading
The arc is catch-up, executed one API generation at a time. Glyph rendering arrived in 1.6-3, GE 15 stubs in 1.6-5 existed only to stop grid from segfaulting, and 1.7-0 delivers the real GE 13/14/16 feature set rather than placeholders. Alongside that, dropping the CAIROGD_VER C API and the mkdist step means the package now builds with plain R CMD build, which reads as deliberate reduction of maintenance overhead.
◆ Prediction
Expect the next releases to be corrective rather than additive: the entries show every API adoption here has been followed by a fix release, and patterns, masks and groups are a much larger surface than glyphs were.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to cairo and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either cairo or TwoSampleMR.
geodist
geodist stays dependency-free and fast, and warns you when 'cheap' distances stop being honest.
errors
errors keeps making uncertainty print the way each scientific field expects.
CMAQ
CMAQ went global in v5.5, and has been patching that surface ever since.
enpls
enpls has not changed its statistics since 2016 — only its website, twice.
grex
grex is a lookup table with a version number — it ships when the annotation moves.
See all cairo alternatives → · See all TwoSampleMR alternatives →
Recent activity from cairo and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 9mo agocairoCairo adds fill patterns, masks and groups (GE API 16) ⚡
- 11mo agocairoCairo 1.6-4: configure cleanup, locatorBell dropped on X11
- 11mo agocairoCairo 1.6-5 stubs GE 15 to stop grid segfaulting
- 2y agocairoCairo 1.6-2
- 2y agocairoCairo 1.6-3 adds glyph rendering for grid.glyph()
Frequently asked questions
What is the difference between cairo and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. cairo and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is cairo better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. cairo and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to cairo?
Top cairo alternatives in Analytics are ranked by recent ship velocity. Browse the "cairo alternatives" section above for the current picks, or visit /alternatives/cairo-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.