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Comparison · Analytics
fastglm vs UCell
A side-by-side editorial comparison of fastglm and UCell — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
fastglm vs UCell: at a glance
What is fastglm?
A fast GLM solver stops being one function and becomes a count-model family
fastglm ran C++ IRLS for standard generalized linear models for six years with almost no releases. In May 2026 it added three top-level model types — negative binomial with jointly estimated dispersion, hurdle, and zero-inflated — each with the entire fitting driver in C++ rather than an R loop around a C++ kernel. The following release generalised Firth bias reduction to every standard family across dense, sparse and streaming backends.
What is UCell?
A rank-based gene signature scorer that has grown by adapting to whatever object format single-cell R uses next
UCell scores gene signatures in single-cell data using a rank-based metric that is robust to dataset composition. Its release history reads as a sequence of ecosystem accommodations: Bioconductor submission in 2.0, SmoothKNN() for k-nearest-neighbor smoothing of scores in 2.2, smoothing applied directly to expression slots in 2.4, Seurat v5 assay compatibility in 2.6, multi-layer Seurat v5 objects in 2.8, and a missing_genes parameter in 2.14 that lets callers impute or skip signature genes absent from the data. Version 2.16 tracks Bioconductor 3.23 and points at a new publication and a Python implementation, pyUCell.
fastglm vs UCell: editorial side-by-side
fastglm
0.0ANALYTICS
A fast GLM solver stops being one function and becomes a count-model family
◆ Current state
fastglm ran C++ IRLS for standard generalized linear models for six years with almost no releases. In May 2026 it added three top-level model types — negative binomial with jointly estimated dispersion, hurdle, and zero-inflated — each with the entire fitting driver in C++ rather than an R loop around a C++ kernel. The following release generalised Firth bias reduction to every standard family across dense, sparse and streaming backends.
◆ Where it's heading
The package changed what it is. Through 0.0.3 it was a drop-in replacement for glm() competing on speed; from 0.1.0 it targets the models people leave base R for — MASS::glm.nb, pscl::hurdle, pscl::zeroinfl — and reimplements their full estimation loops natively. The 0.1.1 follow-up is consolidation on that new surface: Firth generalised past binomial logit, SQUAREM acceleration on the zero-inflation EM driver, and a run of clamping guards and initialization fixes on the families most prone to overflow.
◆ Prediction
The numerical-stability work in 0.1.1 clusters on Tweedie and the inverse and sqrt link families, which suggests those paths are the newest and least exercised — expect further correctness fixes there before new model types.
UCell
0.0ANALYTICS
A rank-based gene signature scorer that has grown by adapting to whatever object format single-cell R uses next
◆ Current state
UCell scores gene signatures in single-cell data using a rank-based metric that is robust to dataset composition. Its release history reads as a sequence of ecosystem accommodations: Bioconductor submission in 2.0, SmoothKNN() for k-nearest-neighbor smoothing of scores in 2.2, smoothing applied directly to expression slots in 2.4, Seurat v5 assay compatibility in 2.6, multi-layer Seurat v5 objects in 2.8, and a missing_genes parameter in 2.14 that lets callers impute or skip signature genes absent from the data. Version 2.16 tracks Bioconductor 3.23 and points at a new publication and a Python implementation, pyUCell.
◆ Where it's heading
Two threads run through this. The scoring algorithm itself has barely changed — the rank-based core is stable, and 2.14's reformatting to gene indices rather than string matching is a speed change, not a method change. What does change constantly is object-format compatibility, which is the tax of living between Seurat and SingleCellExperiment. The pyUCell reference in 2.16 is the first sign of the method reaching beyond R, though these notes say nothing about its scope.
◆ Prediction
The cadence is locked to Bioconductor's twice-yearly release train, so the next version will most likely accompany Bioconductor 3.24 with whatever Seurat or SingleCellExperiment changes it brings.
Alternatives to fastglm and UCell
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either fastglm or UCell.
dynwrap
A dormant trajectory-inference wrapper wakes up for maintenance only
tEDM
The temporal half of the stscl EDM pair, tracking its spatial sibling
spEDM
Spatial causal discovery in R, one exposed method per release
sccore
Shared plumbing for the Kharchenko single-cell stack, updated once a year
rdataone
The R client for DataONE ships slow, correctness-focused maintenance
See all fastglm alternatives → · See all UCell alternatives →
Recent activity from fastglm and UCell
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 2mo agofastglmFirth generalised to all families, plus SQUAREM and stability fixes
- 3mo agofastglmCRAN release 0.1.0 ⚡
- 3mo agoUCellTracks Bioconductor 3.23 and points to a Python port
- 9mo agoUCellUCell version 2.14
- 2y agoUCellUCell version 2.8
- 2y agoUCellUCell version 2.6
- 3y agoUCellUCell version 2.4
- 3y agoUCellUCell version 2.2
- 4y agofastglmC++ headers exposed for linking
- 7y agofastglmFirst CRAN release of the C++ IRLS solver
Frequently asked questions
What is the difference between fastglm and UCell?
Both compete on the same themes — r-package — within Analytics. fastglm and UCell are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is fastglm better than UCell?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. fastglm and UCell are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to fastglm?
Top fastglm alternatives in Analytics are ranked by recent ship velocity. Browse the "fastglm alternatives" section above for the current picks, or visit /alternatives/fastglm for the full list with editorial commentary on each.
What are the best alternatives to UCell?
Top UCell alternatives in Analytics are ranked by recent ship velocity. Browse the "UCell alternatives" section above for the current picks, or visit /alternatives/ucell for the full list with editorial commentary on each.