fillpattern
Pattern fills for ggplot2, hardened against the ways users write sizes
Comparison · Analytics
cTMed vs UCell
A side-by-side editorial comparison of cTMed and UCell — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
cTMed vs UCell: at a glance
What is cTMed?
Continuous-time mediation effects get standardized centrality, six years into steady patch work
cTMed computes direct, indirect and total effects for continuous-time mediation models, with delta-method, Monte Carlo and bootstrap variants of each. Development is a long run of patch releases from the jeksterslab account, roughly every two months, each adding a function or two. The latest adds standardized centrality measures and allows a diagonal sigma across ten standardized estimators.
What is UCell?
A rank-based gene signature scorer that has grown by adapting to whatever object format single-cell R uses next
UCell scores gene signatures in single-cell data using a rank-based metric that is robust to dataset composition. Its release history reads as a sequence of ecosystem accommodations: Bioconductor submission in 2.0, SmoothKNN() for k-nearest-neighbor smoothing of scores in 2.2, smoothing applied directly to expression slots in 2.4, Seurat v5 assay compatibility in 2.6, multi-layer Seurat v5 objects in 2.8, and a missing_genes parameter in 2.14 that lets callers impute or skip signature genes absent from the data. Version 2.16 tracks Bioconductor 3.23 and points at a new publication and a Python implementation, pyUCell.
cTMed vs UCell: editorial side-by-side
cTMed
2.5ANALYTICS
Continuous-time mediation effects get standardized centrality, six years into steady patch work
◆ Current state
cTMed computes direct, indirect and total effects for continuous-time mediation models, with delta-method, Monte Carlo and bootstrap variants of each. Development is a long run of patch releases from the jeksterslab account, roughly every two months, each adding a function or two. The latest adds standardized centrality measures and allows a diagonal sigma across ten standardized estimators.
◆ Where it's heading
The package is filling out a matrix rather than changing shape: for each effect type there is a delta-method, a Monte Carlo and a bootstrap path, and each release closes another cell. The 2025 releases were largely externally forced — an Armadillo 15.0.x transition at CRAN, a citation addition after the Psychological Methods paper landed — which suggests the statistical core has been settled since the 1.0.6 standardization revision.
◆ Prediction
The diagonal-sigma option has now reached the standardized estimators; extending it to the remaining unstandardized variants is the obvious next cell to fill.
UCell
0.0ANALYTICS
A rank-based gene signature scorer that has grown by adapting to whatever object format single-cell R uses next
◆ Current state
UCell scores gene signatures in single-cell data using a rank-based metric that is robust to dataset composition. Its release history reads as a sequence of ecosystem accommodations: Bioconductor submission in 2.0, SmoothKNN() for k-nearest-neighbor smoothing of scores in 2.2, smoothing applied directly to expression slots in 2.4, Seurat v5 assay compatibility in 2.6, multi-layer Seurat v5 objects in 2.8, and a missing_genes parameter in 2.14 that lets callers impute or skip signature genes absent from the data. Version 2.16 tracks Bioconductor 3.23 and points at a new publication and a Python implementation, pyUCell.
◆ Where it's heading
Two threads run through this. The scoring algorithm itself has barely changed — the rank-based core is stable, and 2.14's reformatting to gene indices rather than string matching is a speed change, not a method change. What does change constantly is object-format compatibility, which is the tax of living between Seurat and SingleCellExperiment. The pyUCell reference in 2.16 is the first sign of the method reaching beyond R, though these notes say nothing about its scope.
◆ Prediction
The cadence is locked to Bioconductor's twice-yearly release train, so the next version will most likely accompany Bioconductor 3.24 with whatever Seurat or SingleCellExperiment changes it brings.
Alternatives to cTMed and UCell
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either cTMed or UCell.
gcube
gcube's recent releases are all packaging metadata, not simulation code
cubist
The R port of Quinlan's Cubist gets reproducibility fixes, not new modelling
ggstats
ggstats keeps widening what a coefficient or Likert plot can be
ecodive
ecodive rebuilt itself into a broad diversity-metric library, breaking as it went
simStateSpace
State-space data simulation for R, filled in one function at a time
Recent activity from cTMed and UCell
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 27d agocTMedStandardized centrality measures and diagonal-sigma support
- 3mo agoUCellTracks Bioconductor 3.23 and points to a Python port
- 6mo agocTMedMinor method edits
- 9mo agoUCellUCell version 2.14
- 10mo agocTMedPackage citation added for the Psychological Methods paper
- 10mo agocTMedArmadillo 15.0.x compatibility for CRAN
- 1y agocTMedStandardization reworked around the steady-state covariance matrix
- 1y agocTMedBootstrap centrality estimators and MCPhiSigma()
- 2y agoUCellUCell version 2.8
- 2y agoUCellUCell version 2.6
- 3y agoUCellUCell version 2.4
- 3y agoUCellUCell version 2.2
Frequently asked questions
What is the difference between cTMed and UCell?
Both compete on the same themes — r-package — within Analytics. cTMed is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is cTMed better than UCell?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. cTMed is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to cTMed?
Top cTMed alternatives in Analytics are ranked by recent ship velocity. Browse the "cTMed alternatives" section above for the current picks, or visit /alternatives/ctmed for the full list with editorial commentary on each.
What are the best alternatives to UCell?
Top UCell alternatives in Analytics are ranked by recent ship velocity. Browse the "UCell alternatives" section above for the current picks, or visit /alternatives/ucell for the full list with editorial commentary on each.