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Comparison · Analytics
TwoSampleMR vs watina
A side-by-side editorial comparison of TwoSampleMR and watina — release velocity, themes, recent moves, and the top alternatives to consider.
TwoSampleMR vs watina: at a glance
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
What is watina?
A groundwater database client that has started doing the domain analysis too
watina is the R interface to the Watina groundwater monitoring database, and its history is mostly about making data retrieval correct: filter depths guessed conservatively when missing, spatial masking, aggregation methods per observation well, and a long series of fixes to keep the lazy database queries working across dbplyr versions. The most recent release moves past retrieval into interpretation, adding ionic ratio calculation and a Van Wirdum diagram to plot chemistry data.
TwoSampleMR vs watina: editorial side-by-side
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
watina
0.0ANALYTICS
A groundwater database client that has started doing the domain analysis too
◆ Current state
watina is the R interface to the Watina groundwater monitoring database, and its history is mostly about making data retrieval correct: filter depths guessed conservatively when missing, spatial masking, aggregation methods per observation well, and a long series of fixes to keep the lazy database queries working across dbplyr versions. The most recent release moves past retrieval into interpretation, adding ionic ratio calculation and a Van Wirdum diagram to plot chemistry data.
◆ Where it's heading
The package is drifting from a database client toward a domain toolkit. Early releases fought the data layer — connection handling moved to inbodb, sorting semantics changed, defunct dbplyr calls worked around. Recent work assumes retrieval is solved and adds hydrochemical analysis on top, along with defensive handling for the physically impossible inputs that analysis exposes, such as zero conductivity in the warehouse.
◆ Prediction
Expect further chemistry analysis and plotting helpers rather than new retrieval functions, since that is where the newest release invested and where the accompanying vignette points.
Alternatives to TwoSampleMR and watina
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either TwoSampleMR or watina.
tidytransit
tidytransit tracks the GTFS spec as it grows, one reader and one router feature at a time.
oblicubes
A tiny grid renderer for oblique-projection cubes, complete since its first release.
biocro
BioCro swapped an unstable iteration for real root finders, changing what its crop models compute.
redist
redist keeps rewriting the sampler underneath a district-drawing API it has held stable since 4.0.
epiflows
epiflows has shipped four releases in eight years, none of which changed the code.
See all TwoSampleMR alternatives → · See all watina alternatives →
Recent activity from TwoSampleMR and watina
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agowatinaIonic ratios and Van Wirdum diagrams for chemistry data
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 2y agowatinaKSgeneral moved to Suggests to survive CRAN removal
- 5y agowatinaDataframe input restored after a defunct dbplyr call
- 5y agowatinadbplyr 2.0 compatibility drops the need for a forked dependency
- 5y agowatinaSpatial clustering of wells and richer location attributes
- 6y agowatinaSoil surface calculation fixed after a select() dropped the variable
Frequently asked questions
What is the difference between TwoSampleMR and watina?
They serve adjacent needs but don't currently overlap on shipped themes. TwoSampleMR and watina are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is TwoSampleMR better than watina?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. TwoSampleMR and watina are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.
What are the best alternatives to watina?
Top watina alternatives in Analytics are ranked by recent ship velocity. Browse the "watina alternatives" section above for the current picks, or visit /alternatives/watina-r for the full list with editorial commentary on each.