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epiflows vs TwoSampleMR

A side-by-side editorial comparison of epiflows and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.

epiflows vs TwoSampleMR: at a glance

FeatureepiflowsTwoSampleMR
SectorAnalyticsAnalytics
Velocity score0.00.0
Sparks · 30d00
Top themesr, epidemiology, dormant, maintenancemendelian-randomization, genetic-epidemiology, correctness-fixes, opengwas
Last editorial update1h ago5h ago
WebsiteVisit →Visit →

What is epiflows?

epiflows has shipped four releases in eight years, none of which changed the code.

epiflows predicts the spread of infectious disease along population flows between locations, and it is effectively dormant. The whole visible history spans 2018 to 2026 in four entries: the first CRAN release, a Zenodo archival tag, a Roxygen patch whose notes state the functionality is unchanged, and a 2026 release replacing deprecated ggplot2 and tibble calls. No entry describes new epidemiological capability.

Read the full epiflows trajectory →

What is TwoSampleMR?

The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.

TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.

Read the full TwoSampleMR trajectory →

epiflows vs TwoSampleMR: editorial side-by-side

E
epiflows
ANALYTICS
0.0

epiflows has shipped four releases in eight years, none of which changed the code.

◆ Current state

epiflows predicts the spread of infectious disease along population flows between locations, and it is effectively dormant. The whole visible history spans 2018 to 2026 in four entries: the first CRAN release, a Zenodo archival tag, a Roxygen patch whose notes state the functionality is unchanged, and a 2026 release replacing deprecated ggplot2 and tibble calls. No entry describes new epidemiological capability.

◆ Where it's heading

The package is being kept installable rather than developed. The one recent release is dependency maintenance contributed from outside, which is the pattern for RECON-era epidemiology packages that have outlived their original project funding. Two separate entries are both labelled version 0.2.1, so even the version history is not a reliable guide to what changed.

◆ Prediction

Any further releases will most likely be more deprecation cleanup to keep the package on CRAN; there is nothing in the record suggesting active development has resumed.

T
TwoSampleMR
ANALYTICS
0.0

The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.

◆ Current state

TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.

◆ Where it's heading

The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.

◆ Prediction

Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.

Alternatives to epiflows and TwoSampleMR

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either epiflows or TwoSampleMR.

See all epiflows alternatives → · See all TwoSampleMR alternatives →

Recent activity from epiflows and TwoSampleMR

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
  2. 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
  3. 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
  4. 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
  5. 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
  6. 4mo agoTwoSampleMRFurther internal code optimizations
  7. 5mo agoepiflowsDeprecated ggplot2 and tibble calls replaced
  8. 3y agoepiflowsRoxygen patch for CRAN checks
  9. 7y agoepiflowsFirst Zenodo archival tag
  10. 8y agoepiflowsFirst CRAN release

Frequently asked questions

What is the difference between epiflows and TwoSampleMR?

They serve adjacent needs but don't currently overlap on shipped themes. epiflows and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is epiflows better than TwoSampleMR?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. epiflows and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to epiflows?

Top epiflows alternatives in Analytics are ranked by recent ship velocity. Browse the "epiflows alternatives" section above for the current picks, or visit /alternatives/epiflows-r for the full list with editorial commentary on each.

What are the best alternatives to TwoSampleMR?

Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.