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Comparison · Analytics
SimInf vs TwoSampleMR
A side-by-side editorial comparison of SimInf and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
SimInf vs TwoSampleMR: at a glance
What is SimInf?
SimInf 10.0 turns an epidemic simulator into a tool that fits models to real time series
SimInf simulates stochastic disease spread over networks of nodes, with a model parser that compiles user-specified transitions to C. Version 10.0.0 was a deliberate major break: the SimInf_pfilter S4 class and the bootstrap filtering interface were redesigned, a replicates slot was added to SimInf_model, a multi-particle variant of the split-step solver arrived, and the package gained Particle Markov Chain Monte Carlo fitting against observed time series. The follow-up 10.1.0 is a single zero-length memcpy fix found by CRAN's M1 checks.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
SimInf vs TwoSampleMR: editorial side-by-side
SimInf
0.0ANALYTICS
SimInf 10.0 turns an epidemic simulator into a tool that fits models to real time series
◆ Current state
SimInf simulates stochastic disease spread over networks of nodes, with a model parser that compiles user-specified transitions to C. Version 10.0.0 was a deliberate major break: the SimInf_pfilter S4 class and the bootstrap filtering interface were redesigned, a replicates slot was added to SimInf_model, a multi-particle variant of the split-step solver arrived, and the package gained Particle Markov Chain Monte Carlo fitting against observed time series. The follow-up 10.1.0 is a single zero-length memcpy fix found by CRAN's M1 checks.
◆ Where it's heading
The package has been moving from simulation toward inference for several releases. The 9.x line built the input side — utilities for cleaning raw individual event data, variables and enumeration constants in the model parser — and 10.0.0 closed the loop by making the simulator fittable to data through PMCMC. The version number was incremented precisely because that required breaking the particle filter interface.
◆ Prediction
Fitting machinery this new usually needs a second pass on usability, so the next releases most likely focus on diagnostics and documentation around PMCMC rather than on the simulation core, which has been stable across the whole 9.x and 10.x history.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to SimInf and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either SimInf or TwoSampleMR.
rjdqa
rjdqa keeps refining one screen: the seasonal adjustment quality dashboard
epikit
epikit narrows to field-epidemiology helpers, handing proportions to a sibling package
mutagen
A young package porting Stata's egen row-wise helpers to the tidyverse, one function per release
broman
A statistician's personal toolbox, growing one plotting utility at a time
qtl
R/qtl is in pure custodial mode: every recent release answers a compiler, not a user
See all SimInf alternatives → · See all TwoSampleMR alternatives →
Recent activity from SimInf and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 9mo agoSimInfAvoid memcpy on zero-length continuous state vector
- 9mo agoSimInfPMCMC fitting arrives; particle filter interface redesigned ⚡
- 2y agoSimInfDocumentation link anchors; parser dependency fix
- 2y agoSimInfModel parser gains variables and enumeration constants
- 2y agoSimInfindividual_events() added for raw event data cleaning
- 3y agoSimInfConfigure script uses R to locate the compiler
Frequently asked questions
What is the difference between SimInf and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. SimInf and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is SimInf better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. SimInf and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to SimInf?
Top SimInf alternatives in Analytics are ranked by recent ship velocity. Browse the "SimInf alternatives" section above for the current picks, or visit /alternatives/siminf-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.