rollupTree
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Comparison · Infra & APIs
PEIMAN2 vs slendr
A side-by-side editorial comparison of PEIMAN2 and slendr — release velocity, themes, recent moves, and the top alternatives to consider.
PEIMAN2 vs slendr: at a glance
What is PEIMAN2?
PEIMAN2 cut its annotation database loose from its release cycle without breaking CRAN.
PEIMAN2 does enrichment analysis over post-translational modifications, testing whether a protein list is enriched for particular PTMs against UniProt-derived annotations, with translation functions bridging to mass spectrometry workflows. Its answers are only as current as its bundled database, and until June that database could only be refreshed by releasing a new package version. Version 1.1.0 changes that.
What is slendr?
Population-genetic simulation in R, opened up to selection and finally easier to install.
slendr specifies spatial and non-spatial population-genetic models in R and simulates them through SLiM or msprime, returning tree sequences that tskit then analyses. Two threads dominate the current releases: keeping in step with fast-moving backends, with SLiM 5.1, pyslim 1.1.0 and Python 3.13 now required, and reducing the setup burden that its Python dependency imposes. Version 1.5.0 adds ephemeral uv-based virtual environments, so init_env(uv = TRUE) can stand in for creating a permanent environment with setup_env().
PEIMAN2 vs slendr: editorial side-by-side
PEIMAN2
0.0INFRA · APIS
PEIMAN2 cut its annotation database loose from its release cycle without breaking CRAN.
◆ Current state
PEIMAN2 does enrichment analysis over post-translational modifications, testing whether a protein list is enriched for particular PTMs against UniProt-derived annotations, with translation functions bridging to mass spectrometry workflows. Its answers are only as current as its bundled database, and until June that database could only be refreshed by releasing a new package version. Version 1.1.0 changes that.
◆ Where it's heading
The package has been moving from a fixed snapshot toward versioned, user-selectable data. Earlier releases updated the bundled database in place — 1.0.0 shipped the March 2025 version and said little else — which meant the annotation vintage was whatever the package version implied. Now update_peiman_database() downloads and caches external database files and UniProt PTM lists, enrichment workflows take a database_version argument, and the mass-spec translators take a ptmlist_version, so an analysis can pin a dated database rather than a package release. The CRAN-safe default is preserved deliberately: loading, examples and checks still use the bundled internal data and need no network.
◆ Prediction
Version pinning is now expressible but the release notes do not describe how a chosen version is recorded in output, so surfacing the active database version in results is the natural companion. The database and the UniProt PTM list are versioned separately, which leaves room for a combined manifest.
slendr
0.0INFRA · APIS
Population-genetic simulation in R, opened up to selection and finally easier to install.
◆ Current state
slendr specifies spatial and non-spatial population-genetic models in R and simulates them through SLiM or msprime, returning tree sequences that tskit then analyses. Two threads dominate the current releases: keeping in step with fast-moving backends, with SLiM 5.1, pyslim 1.1.0 and Python 3.13 now required, and reducing the setup burden that its Python dependency imposes. Version 1.5.0 adds ephemeral uv-based virtual environments, so init_env(uv = TRUE) can stand in for creating a permanent environment with setup_env().
◆ Where it's heading
Since the 1.0.0 release added non-neutral simulation, the work has shifted from capability to friction. A large share of recent notes concerns Python environment handling, conda activation races on Windows, dependency pruning that made shiny optional, and argument names that misled users, as when gene_flow()'s rate argument turned out to mean total ancestry proportion rather than a rate. That is the profile of a package whose scientific surface is settled and whose remaining problems are the ones users actually hit.
◆ Prediction
Expect the uv-based environment path to move from fallback to default once it has proven itself, given the notes already describe an environment variable for making it so. The deprecated rate argument in gene_flow() is explicitly slated for removal in a future major release, which is the clearest signal here of what a 2.0 would contain.
Alternatives to PEIMAN2 and slendr
Other Infra & APIs products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either PEIMAN2 or slendr.
massProps
A mass-properties rollup spends a year on documentation and follows its sibling's API
writeAlizer
Six months of releases and not one of them touched the scoring models
samplr
A cognitive-science sampling package ships once, then goes quiet for eighteen months
stochvol
A Bayesian volatility sampler in its maintenance decade, paying for its own speed
midr
A black-box interpreter reaches CRAN, then learns multi-class and survival responses
See all PEIMAN2 alternatives → · See all slendr alternatives →
Recent activity from PEIMAN2 and slendr
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoslendrEphemeral uv Python environments remove the setup step
- 2mo agoPEIMAN2Database updates decouple from package releases ⚡
- 7mo agoslendrgene_flow() separates migration rate from ancestry proportion
- 9mo agoslendrshiny made optional; SLiM 5.1 and Python 3.13 required
- 1y agoslendrconda activation reverted to a slower but reliable path
- 1y agoslendrBackends raised to SLiM 5.0, tskit 0.6.4 and msprime 1.3.4
- 1y agoPEIMAN2Bundled database refreshed to the March 2025 UniProt vintage
- 1y agoPEIMAN2Documentation fix for the second example dataset
- 1y agoslendrNon-neutral models arrive; slim() interface simplified ⚡
- 2y agoPEIMAN2Background lists for SEA and PSEA; tidyverse dependency dropped
Frequently asked questions
What is the difference between PEIMAN2 and slendr?
They serve adjacent needs but don't currently overlap on shipped themes. PEIMAN2 and slendr are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is PEIMAN2 better than slendr?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. PEIMAN2 and slendr are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Infra & APIs products to evaluate alongside.
What are the best alternatives to PEIMAN2?
Top PEIMAN2 alternatives in Infra & APIs are ranked by recent ship velocity. Browse the "PEIMAN2 alternatives" section above for the current picks, or visit /alternatives/peiman2 for the full list with editorial commentary on each.
What are the best alternatives to slendr?
Top slendr alternatives in Infra & APIs are ranked by recent ship velocity. Browse the "slendr alternatives" section above for the current picks, or visit /alternatives/slendr for the full list with editorial commentary on each.