n2kanalysis
n2kanalysis has spent eight years wiring INLA models to an S3 bucket.
Comparison · Analytics
mrbayes vs TwoSampleMR
A side-by-side editorial comparison of mrbayes and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:mendelian-randomization
mrbayes vs TwoSampleMR: at a glance
What is mrbayes?
mrbayes spent 2026 auditing its own Bayesian MR estimators for coding errors.
mrbayes wraps Stan and JAGS implementations of Bayesian Mendelian randomization estimators — IVW, MR-Egger, radial Egger, and their multivariable forms. Most of the visible history is packaging work: dependency trimming, conditional examples so the package installs where JAGS will not compile, a maintainer handover. The 0.5.3 release in July 2026 breaks that pattern with a dense list of fixes inside the model code itself.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
mrbayes vs TwoSampleMR: editorial side-by-side
mrbayes
0.0ANALYTICS
mrbayes spent 2026 auditing its own Bayesian MR estimators for coding errors.
◆ Current state
mrbayes wraps Stan and JAGS implementations of Bayesian Mendelian randomization estimators — IVW, MR-Egger, radial Egger, and their multivariable forms. Most of the visible history is packaging work: dependency trimming, conditional examples so the package installs where JAGS will not compile, a maintainer handover. The 0.5.3 release in July 2026 breaks that pattern with a dense list of fixes inside the model code itself.
◆ Where it's heading
The package has moved from packaging upkeep into a correctness-audit phase. 0.5.3 fixes a hardcoded three-exposure loop in MVMR-Egger reporting, a broken joint-prior branch, a sigma parameterization error in radial Egger, and several prior specifications — the profile of a maintainer reading their own model files closely rather than responding to bug reports. Platform work continues underneath: an R 4.3.0 floor inherited through a transitive dependency chain, and segfault fixes on macOS ARM.
◆ Prediction
Expect further audit-driven patches to the remaining rjags and Stan model files rather than new estimators; the fixes in 0.5.3 cluster in the Egger variants, which suggests that is where the reading is still in progress.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to mrbayes and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either mrbayes or TwoSampleMR.
n1qn1c
A Fortran-descended optimizer got thread-safe, then found two flags that never worked.
ggstatsplot
ggstatsplot reached 1.0 by adding tests, having outsourced its statistics years ago.
collapse
collapse got a JSS paper and a 7x fmean speedup in the same release.
gtsummary
gtsummary is quietly rebuilding itself around analysis results data, one table verb at a time.
broadcast
broadcast is filling in NumPy-style array broadcasting for R, operator by operator.
See all mrbayes alternatives → · See all TwoSampleMR alternatives →
Recent activity from mrbayes and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agomrbayesEstimator audit fixes MVMR-Egger loops and radial Egger sigma
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 1y agomrbayesMVMR rjags example gated on rjags being installed
- 1y agomrbayesExamples and tests skip when rstan or rjags is missing
- 1y agomrbayespkgdown site updated
- 1y agomrbayesHelper command added for installing JAGS
- 1y agomrbayesDependency surface trimmed; maintainer handover
Frequently asked questions
What is the difference between mrbayes and TwoSampleMR?
Both compete on the same themes — mendelian-randomization — within Analytics. mrbayes and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is mrbayes better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. mrbayes and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to mrbayes?
Top mrbayes alternatives in Analytics are ranked by recent ship velocity. Browse the "mrbayes alternatives" section above for the current picks, or visit /alternatives/mrbayes for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.