rjd3highfreq
rjd3highfreq ships whatever the Java side ships, and only occasionally says what that was.
Comparison · Analytics
mrbayes vs n1qn1c
A side-by-side editorial comparison of mrbayes and n1qn1c — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
mrbayes vs n1qn1c: at a glance
What is mrbayes?
mrbayes spent 2026 auditing its own Bayesian MR estimators for coding errors.
mrbayes wraps Stan and JAGS implementations of Bayesian Mendelian randomization estimators — IVW, MR-Egger, radial Egger, and their multivariable forms. Most of the visible history is packaging work: dependency trimming, conditional examples so the package installs where JAGS will not compile, a maintainer handover. The 0.5.3 release in July 2026 breaks that pattern with a dense list of fixes inside the model code itself.
What is n1qn1c?
A Fortran-descended optimizer got thread-safe, then found two flags that never worked.
n1qn1c is a quasi-Newton optimization routine translated from Fortran to C, used as a solver backend by the nlmixr2 modeling stack rather than called directly by most users. Its two 2026 releases are a concentrated safety pass: global state converted to thread_local, static removed from local variables in the translated code, integer overflow guards added, and memory leaks closed in the R callback wrappers — plus the gcc-asan and valgrind fixes CRAN asked for.
mrbayes vs n1qn1c: editorial side-by-side
mrbayes
0.0ANALYTICS
mrbayes spent 2026 auditing its own Bayesian MR estimators for coding errors.
◆ Current state
mrbayes wraps Stan and JAGS implementations of Bayesian Mendelian randomization estimators — IVW, MR-Egger, radial Egger, and their multivariable forms. Most of the visible history is packaging work: dependency trimming, conditional examples so the package installs where JAGS will not compile, a maintainer handover. The 0.5.3 release in July 2026 breaks that pattern with a dense list of fixes inside the model code itself.
◆ Where it's heading
The package has moved from packaging upkeep into a correctness-audit phase. 0.5.3 fixes a hardcoded three-exposure loop in MVMR-Egger reporting, a broken joint-prior branch, a sigma parameterization error in radial Egger, and several prior specifications — the profile of a maintainer reading their own model files closely rather than responding to bug reports. Platform work continues underneath: an R 4.3.0 floor inherited through a transitive dependency chain, and segfault fixes on macOS ARM.
◆ Prediction
Expect further audit-driven patches to the remaining rjags and Stan model files rather than new estimators; the fixes in 0.5.3 cluster in the Egger variants, which suggests that is where the reading is still in progress.
n1qn1c
0.0ANALYTICS
A Fortran-descended optimizer got thread-safe, then found two flags that never worked.
◆ Current state
n1qn1c is a quasi-Newton optimization routine translated from Fortran to C, used as a solver backend by the nlmixr2 modeling stack rather than called directly by most users. Its two 2026 releases are a concentrated safety pass: global state converted to thread_local, static removed from local variables in the translated code, integer overflow guards added, and memory leaks closed in the R callback wrappers — plus the gcc-asan and valgrind fixes CRAN asked for.
◆ Where it's heading
The package is being hardened for use inside a parallel modeling framework rather than extended. The audit that produced the thread-safety work also surfaced two plain bugs in features users would have assumed worked: restart = TRUE left the mode at 2 instead of 3 because of a typo, and assign = TRUE referenced the wrong field name so the compressed Hessian was never written to the supplied environment. Earlier work points the same direction — the 6.0.1-12 function-pointer interface exists so nlmixr2est does not need resubmission when this package changes.
◆ Prediction
Expect further memory-safety and sanitizer work rather than algorithmic change; a Fortran-translated numerical core under CRAN's checking regime generates that kind of release indefinitely.
Alternatives to mrbayes and n1qn1c
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Recent activity from mrbayes and n1qn1c
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agomrbayesEstimator audit fixes MVMR-Egger loops and radial Egger sigma
- 4mo agon1qn1crestart and assign flags fixed; sanitizer issues cleared
- 4mo agon1qn1cGlobal state converted to thread_local
- 1y agon1qn1cFunction-pointer API decouples nlmixr2est releases
- 1y agomrbayesMVMR rjags example gated on rjags being installed
- 1y agomrbayesExamples and tests skip when rstan or rjags is missing
- 1y agomrbayespkgdown site updated
- 1y agomrbayesHelper command added for installing JAGS
- 1y agomrbayesDependency surface trimmed; maintainer handover
Frequently asked questions
What is the difference between mrbayes and n1qn1c?
Both compete on the same themes — r-package — within Analytics. mrbayes and n1qn1c are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is mrbayes better than n1qn1c?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. mrbayes and n1qn1c are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to mrbayes?
Top mrbayes alternatives in Analytics are ranked by recent ship velocity. Browse the "mrbayes alternatives" section above for the current picks, or visit /alternatives/mrbayes for the full list with editorial commentary on each.
What are the best alternatives to n1qn1c?
Top n1qn1c alternatives in Analytics are ranked by recent ship velocity. Browse the "n1qn1c alternatives" section above for the current picks, or visit /alternatives/n1qn1c for the full list with editorial commentary on each.