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The tidy front-end for GAMs, now stable enough that upstream ggplot2 sets its release calendar.
Comparison · Analytics
cTMed vs GeneNMF
A side-by-side editorial comparison of cTMed and GeneNMF — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
cTMed vs GeneNMF: at a glance
What is cTMed?
Continuous-time mediation effects get standardized centrality, six years into steady patch work
cTMed computes direct, indirect and total effects for continuous-time mediation models, with delta-method, Monte Carlo and bootstrap variants of each. Development is a long run of patch releases from the jeksterslab account, roughly every two months, each adding a function or two. The latest adds standardized centrality measures and allows a diagonal sigma across ten standardized estimators.
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
cTMed vs GeneNMF: editorial side-by-side
cTMed
2.5ANALYTICS
Continuous-time mediation effects get standardized centrality, six years into steady patch work
◆ Current state
cTMed computes direct, indirect and total effects for continuous-time mediation models, with delta-method, Monte Carlo and bootstrap variants of each. Development is a long run of patch releases from the jeksterslab account, roughly every two months, each adding a function or two. The latest adds standardized centrality measures and allows a diagonal sigma across ten standardized estimators.
◆ Where it's heading
The package is filling out a matrix rather than changing shape: for each effect type there is a delta-method, a Monte Carlo and a bootstrap path, and each release closes another cell. The 2025 releases were largely externally forced — an Armadillo 15.0.x transition at CRAN, a citation addition after the Psychological Methods paper landed — which suggests the statistical core has been settled since the 1.0.6 standardization revision.
◆ Prediction
The diagonal-sigma option has now reached the standardized estimators; extending it to the remaining unstandardized variants is the obvious next cell to fill.
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
Alternatives to cTMed and GeneNMF
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either cTMed or GeneNMF.
incase
A safer case_when that keeps hardening its guarantees while realigning to tidyverse naming.
reda
A mature recurrent-event toolkit in careful maintenance, shedding weight rather than adding surface.
TidyDensity
A distribution catalogue that grows by one family at a time, and rarely breaks anything.
cfbfastr
College football's open data client hit v2 — and now reports how many API calls you have left.
rnpn
The USA phenology data client rebuilt its entire stack and stopped handing users -9999 as a number.
See all cTMed alternatives → · See all GeneNMF alternatives →
Recent activity from cTMed and GeneNMF
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 27d agocTMedStandardized centrality measures and diagonal-sigma support
- 6mo agocTMedMinor method edits
- 10mo agocTMedPackage citation added for the Psychological Methods paper
- 10mo agocTMedArmadillo 15.0.x compatibility for CRAN
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agocTMedStandardization reworked around the steady-state covariance matrix
- 1y agocTMedBootstrap centrality estimators and MCPhiSigma()
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
Frequently asked questions
What is the difference between cTMed and GeneNMF?
Both compete on the same themes — r-package — within Analytics. cTMed is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is cTMed better than GeneNMF?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. cTMed is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to cTMed?
Top cTMed alternatives in Analytics are ranked by recent ship velocity. Browse the "cTMed alternatives" section above for the current picks, or visit /alternatives/ctmed for the full list with editorial commentary on each.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.