n2kanalysis
n2kanalysis has spent eight years wiring INLA models to an S3 bucket.
Comparison · Analytics
rncl vs TwoSampleMR
A side-by-side editorial comparison of rncl and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
rncl vs TwoSampleMR: at a glance
What is rncl?
A phylogenetics parser on life support, shipping only what CRAN's compilers demand.
rncl wraps the Nexus Class Library so R can read Newick and NEXUS tree files. Every release since 2016 has been custodial: 0.8.9 exists solely to pull upstream NCL changes so the bundled C++ compiles under the C++20 standard. No user-facing function has changed in close to a decade.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
rncl vs TwoSampleMR: editorial side-by-side
rncl
2.5ANALYTICS
A phylogenetics parser on life support, shipping only what CRAN's compilers demand.
◆ Current state
rncl wraps the Nexus Class Library so R can read Newick and NEXUS tree files. Every release since 2016 has been custodial: 0.8.9 exists solely to pull upstream NCL changes so the bundled C++ compiles under the C++20 standard. No user-facing function has changed in close to a decade.
◆ Where it's heading
The release cadence tracks toolchain deprecations rather than user demand: gcc 12 removing binary_function in 2022, a deprecated Rcpp call in 2025, C++20 in 2026. The package is maintained as a stable parsing dependency for phylogenetics tooling, and the goal visible in these entries is keeping it installable, not extending it.
◆ Prediction
Expect the next release only when a compiler or CRAN policy change breaks the build again; nothing in these entries points to new parsing features.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to rncl and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either rncl or TwoSampleMR.
n1qn1c
A Fortran-descended optimizer got thread-safe, then found two flags that never worked.
ggstatsplot
ggstatsplot reached 1.0 by adding tests, having outsourced its statistics years ago.
collapse
collapse got a JSS paper and a 7x fmean speedup in the same release.
gtsummary
gtsummary is quietly rebuilding itself around analysis results data, one table verb at a time.
broadcast
broadcast is filling in NumPy-style array broadcasting for R, operator by operator.
See all rncl alternatives → · See all TwoSampleMR alternatives →
Recent activity from rncl and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 15d agornclNCL sources refreshed for C++20 compilation
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 8mo agornclDeprecated Rcpp call removed in maintenance release
- 4y agornclBuild fixed for gcc 12 and clang 14
- 6y agornclMaintenance release clearing CRAN check warnings
- 8y agornclCRAN check notes and warnings cleared
- 9y agornclSingleton removal moves to C++ for a 3x speedup
Frequently asked questions
What is the difference between rncl and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. rncl is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is rncl better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. rncl is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to rncl?
Top rncl alternatives in Analytics are ranked by recent ship velocity. Browse the "rncl alternatives" section above for the current picks, or visit /alternatives/rncl-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.