nflreadr
The nflverse data loader, whose releases are dictated by the NFL calendar and CRAN's archive policy
Comparison · Analytics
qtl2 vs susier
A side-by-side editorial comparison of qtl2 and susier — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:statistical-geneticsr-package
qtl2 vs susier: at a glance
What is qtl2?
The standard QTL mapping package in R opened its genome scan to user-supplied likelihood models.
qtl2 is the R toolkit for QTL mapping in experimental crosses, covering genotype probability calculation, genome scans with and without polygenic effects, permutation testing, SNP association, and the plotting that goes with them. The last year of work has pushed hard in two directions: tooling for high-throughput expression and protein QTL studies, and a generalisation of the scan engine itself so the log-likelihood being maximised can be supplied by the user. Note that the release history reached this feed out of order, so feed position is not a reliable guide to which release came first.
What is susier?
Fine-mapping workhorse susieR spends its releases hunting null-effect trimming bugs
susieR implements the Sum of Single Effects regression model for variable selection and fine-mapping, widely used in statistical genetics. The recent releases are a tight run of correctness work concentrated in one area: null effect trimming. Version 0.15.55 fixed trimming under the Servin-Stephens residual variance method, 0.15.56 fixed it again for non-uniform prior weights fourteen minutes later, 0.15.57 corrected an ELBO null space term for RSS with X and a matrix symmetry check, and 0.15.58 addressed an alpha0/beta0 issue. Version 0.16.0 migrates the C++ bindings from Rcpp to cpp11 with cpp11armadillo.
qtl2 vs susier: editorial side-by-side
qtl2
2.5ANALYTICS
The standard QTL mapping package in R opened its genome scan to user-supplied likelihood models.
◆ Current state
qtl2 is the R toolkit for QTL mapping in experimental crosses, covering genotype probability calculation, genome scans with and without polygenic effects, permutation testing, SNP association, and the plotting that goes with them. The last year of work has pushed hard in two directions: tooling for high-throughput expression and protein QTL studies, and a generalisation of the scan engine itself so the log-likelihood being maximised can be supplied by the user. Note that the release history reached this feed out of order, so feed position is not a reliable guide to which release came first.
◆ Where it's heading
The eQTL and pQTL direction is the clearest thread — cis-trans plots, hotspot counting over a sliding window, multi-trait scan heat maps, and genome-wide genotype plots all arrived together, which is the toolkit an experiment with thousands of traits needs rather than one with a handful. Running underneath it is a steady generalisation of the core: a scan function that accepts an arbitrary likelihood, permutations that work with alternative scan functions, full variance-covariance output from single-position fits. Performance and parallelism get attention each cycle, including a more considerate default that leaves one core free. The rest is the ordinary maintenance of a long-lived package — renames to avoid tidyverse collisions, compiler warnings, and correctness fixes on specific cross types.
◆ Prediction
With scan1gen and permutation support for alternative scan functions in place, the natural next step is more model types built on that hook rather than more special-cased scan functions; the entries do not indicate which models are planned.
susier
0.0ANALYTICS
Fine-mapping workhorse susieR spends its releases hunting null-effect trimming bugs
◆ Current state
susieR implements the Sum of Single Effects regression model for variable selection and fine-mapping, widely used in statistical genetics. The recent releases are a tight run of correctness work concentrated in one area: null effect trimming. Version 0.15.55 fixed trimming under the Servin-Stephens residual variance method, 0.15.56 fixed it again for non-uniform prior weights fourteen minutes later, 0.15.57 corrected an ELBO null space term for RSS with X and a matrix symmetry check, and 0.15.58 addressed an alpha0/beta0 issue. Version 0.16.0 migrates the C++ bindings from Rcpp to cpp11 with cpp11armadillo.
◆ Where it's heading
The version-number churn understates how narrow this work is — four consecutive releases touching the same trimming and residual-variance machinery suggests one area where the implementation and the intended behavior had drifted apart. The 0.16.0 binding migration is the only structural change, and it is invisible to users while mattering for build portability and long-term maintenance. Development is clearly active, with automated release tooling and dependency bumps flowing through the same stream.
◆ Prediction
With the binding migration just landed, near-term releases are likely to address fallout from it alongside continued fixes in the same trimming and residual-variance code.
Alternatives to qtl2 and susier
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either qtl2 or susier.
UCell
A rank-based gene signature scorer that has grown by adapting to whatever object format single-cell R uses next
detectseparation
A diagnostic package that generalized past its own name, then learned to say which kind of separation it found
brglm2
A bias-reduction package reaches 1.0 by adding an estimator built for high-dimensional logistic regression
bayestools
The JAGS toolkit under RoBMA, shipping the standardization machinery its downstream rewrite needed
robma
RoBMA 4.0 tears out its own constructor surface and rebuilds on one class hierarchy
Recent activity from qtl2 and susier
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 27d agoqtl2chr_lengths() extended to cross2 objects
- 1mo agoqtl2A genome scan that takes your own likelihood function ⚡
- 2mo agoqtl2Hotspot counting and cis-trans plots for eQTL studies
- 3mo agoqtl2Confidence interval plotting, plus a documentation correction
- 3mo agosusierMigrates C++ bindings from Rcpp to cpp11 and cpp11armadillo
- 3mo agosusierFixes alpha0/beta0 handling under Servin-Stephens
- 4mo agosusierCorrects the null space ELBO term for RSS with X
- 5mo agosusierFixes null effect trimming with non-uniform prior weights
- 5mo agosusierFixes null effect trimming under Servin-Stephens estimation
- 1y agoqtl2Finer-grained parallelism for kinship-based scans
- 1y agoqtl2CSV readers renamed to avoid the readr collision
Frequently asked questions
What is the difference between qtl2 and susier?
Both compete on the same themes — statistical-genetics, r-package — within Analytics. qtl2 is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is qtl2 better than susier?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. qtl2 is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to qtl2?
Top qtl2 alternatives in Analytics are ranked by recent ship velocity. Browse the "qtl2 alternatives" section above for the current picks, or visit /alternatives/qtl2 for the full list with editorial commentary on each.
What are the best alternatives to susier?
Top susier alternatives in Analytics are ranked by recent ship velocity. Browse the "susier alternatives" section above for the current picks, or visit /alternatives/susier for the full list with editorial commentary on each.