n2kanalysis
n2kanalysis has spent eight years wiring INLA models to an S3 bucket.
Comparison · Analytics
OHPL vs TwoSampleMR
A side-by-side editorial comparison of OHPL and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
OHPL vs TwoSampleMR: at a glance
What is OHPL?
A 2017 chemometrics method frozen in place, visited only when CRAN changes its documentation rules.
OHPL implements ordered homogeneity pursuit lasso, a variable selection method for high-dimensional spectroscopic data that groups correlated predictors before applying a lasso. The functional package was complete by 1.2 in 2017, when prediction, performance evaluation and simulated data generation functions were added. Every release since has touched documentation and packaging only.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
OHPL vs TwoSampleMR: editorial side-by-side
OHPL
0.0ANALYTICS
A 2017 chemometrics method frozen in place, visited only when CRAN changes its documentation rules.
◆ Current state
OHPL implements ordered homogeneity pursuit lasso, a variable selection method for high-dimensional spectroscopic data that groups correlated predictors before applying a lasso. The functional package was complete by 1.2 in 2017, when prediction, performance evaluation and simulated data generation functions were added. Every release since has touched documentation and packaging only.
◆ Where it's heading
This is a published-method package in the archival phase: the algorithm is fixed, the paper is cited, and the maintainer keeps it installable. The releases read as a timeline of R packaging conventions rather than of the method — tidyverse code style in 2019, roxygen2 Markdown and bibentry() in 2024, Rd HTML validation in 2026. Gaps of two to five years between releases are normal here.
◆ Prediction
Expect the next release whenever CRAN introduces another documentation or packaging check; there is no indication the method itself will be extended.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to OHPL and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either OHPL or TwoSampleMR.
n1qn1c
A Fortran-descended optimizer got thread-safe, then found two flags that never worked.
ggstatsplot
ggstatsplot reached 1.0 by adding tests, having outsourced its statistics years ago.
collapse
collapse got a JSS paper and a 7x fmean speedup in the same release.
gtsummary
gtsummary is quietly rebuilding itself around analysis results data, one table verb at a time.
broadcast
broadcast is filling in NumPy-style array broadcasting for R, operator by operator.
See all OHPL alternatives → · See all TwoSampleMR alternatives →
Recent activity from OHPL and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoOHPLRd documentation HTML validation fixed
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 2y agoOHPLDocumentation modernized to current R conventions
- 7y agoOHPLCode restyled and repository links updated
- 9y agoOHPLCitation information and documentation site updated
- 9y agoOHPLPrediction and evaluation functions complete the package
Frequently asked questions
What is the difference between OHPL and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. OHPL and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is OHPL better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. OHPL and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to OHPL?
Top OHPL alternatives in Analytics are ranked by recent ship velocity. Browse the "OHPL alternatives" section above for the current picks, or visit /alternatives/ohpl for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.