n2kanalysis
n2kanalysis has spent eight years wiring INLA models to an S3 bucket.
Comparison · Analytics
lineup2 vs TwoSampleMR
A side-by-side editorial comparison of lineup2 and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
lineup2 vs TwoSampleMR: at a glance
What is lineup2?
lineup2 ships once every few years, and 2026's release is a logo and a core-count tweak.
lineup2 provides distance-based tools for detecting sample mix-ups between related datasets — comparing rows and columns of two matrices to find swapped or mislabeled samples. Its visible history is four releases spread across six years, and the capability surface has barely moved since plot_sample() and the propdiff distance arrived in 0.4. Version 0.8 in July 2026 adds a package logo and redefines cores=0 to mean all-but-one core.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
lineup2 vs TwoSampleMR: editorial side-by-side
lineup2
0.0ANALYTICS
lineup2 ships once every few years, and 2026's release is a logo and a core-count tweak.
◆ Current state
lineup2 provides distance-based tools for detecting sample mix-ups between related datasets — comparing rows and columns of two matrices to find swapped or mislabeled samples. Its visible history is four releases spread across six years, and the capability surface has barely moved since plot_sample() and the propdiff distance arrived in 0.4. Version 0.8 in July 2026 adds a package logo and redefines cores=0 to mean all-but-one core.
◆ Where it's heading
This is a finished, single-purpose package in maintenance. The substantive changes across the whole window are plotting conveniences and one parallelism default; nothing in the entries points at new distance measures, new input formats, or expanded scope. The release cadence — five years between 0.6 and 0.8 — reads as a tool the author considers done.
◆ Prediction
Further releases are likely to stay small: a plotting option, a parallelism detail, or a check-farm fix. The entries give no signal of planned feature work.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to lineup2 and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either lineup2 or TwoSampleMR.
n1qn1c
A Fortran-descended optimizer got thread-safe, then found two flags that never worked.
ggstatsplot
ggstatsplot reached 1.0 by adding tests, having outsourced its statistics years ago.
collapse
collapse got a JSS paper and a 7x fmean speedup in the same release.
gtsummary
gtsummary is quietly rebuilding itself around analysis results data, one table verb at a time.
broadcast
broadcast is filling in NumPy-style array broadcasting for R, operator by operator.
See all lineup2 alternatives → · See all TwoSampleMR alternatives →
Recent activity from lineup2 and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agolineup2cores=0 now leaves one core free
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 5y agolineup2plot_sample() gains xlim and ylim control
- 5y agolineup2plot_sample() and the propdiff distance added
- 5y agolineup2Package description revised for CRAN resubmission
Frequently asked questions
What is the difference between lineup2 and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. lineup2 and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is lineup2 better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. lineup2 and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to lineup2?
Top lineup2 alternatives in Analytics are ranked by recent ship velocity. Browse the "lineup2 alternatives" section above for the current picks, or visit /alternatives/lineup2-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.