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Comparison · Analytics

gsDesign2 vs Holistics

A side-by-side editorial comparison of gsDesign2 and Holistics — release velocity, themes, recent moves, and the top alternatives to consider.

gsDesign2 vs Holistics: at a glance

FeaturegsDesign2Holistics
SectorAnalyticsAnalytics
Velocity score3.85.0
Sparks · 30d10
Top themesclinical-trials, group-sequential, biostatistics, pharmaversebusiness-intelligence, ai-governance, analytics-as-code, access-control
Last editorial update4d ago1d ago
WebsiteVisit →Visit →

What is gsDesign2?

Group sequential design tooling that now monitors for harm, not just efficacy and futility.

gsDesign2 is the Merck-authored R package for group sequential clinical trial design under non-proportional hazards, and it has spent the last two years filling in the statistical surface its predecessor gsDesign established. Recent releases added conditional power (gs_cp, gs_cp_npe), sequential p-values, risk-difference designs with minimal risk weighting, and boundary updates from blinded interim estimates. Version 1.2.0 adds harm boundaries across the AHR and NPE design and power functions, wired through every summary and table export path.

Read the full gsDesign2 trajectory →

What is Holistics?

Holistics is adding governance to the AI layer it spent the summer building.

Holistics ships small, frequent notes - often one or two sentences - covering three strands at once: AI features in Explore and Chat, as-code control over presentation through AML, and workspace hygiene like file history and dark mode. The August entries turn to the AI layer's edges rather than its capabilities, with an AI user attribute for restricting what the assistant can reach. Several entries are barely a line long, so scope frequently has to be read from the headline.

Read the full Holistics trajectory →

gsDesign2 vs Holistics: editorial side-by-side

G
gsDesign2
ANALYTICS
3.8

Group sequential design tooling that now monitors for harm, not just efficacy and futility.

◆ Current state

gsDesign2 is the Merck-authored R package for group sequential clinical trial design under non-proportional hazards, and it has spent the last two years filling in the statistical surface its predecessor gsDesign established. Recent releases added conditional power (gs_cp, gs_cp_npe), sequential p-values, risk-difference designs with minimal risk weighting, and boundary updates from blinded interim estimates. Version 1.2.0 adds harm boundaries across the AHR and NPE design and power functions, wired through every summary and table export path.

◆ Where it's heading

The package is converging on parity with gsDesign while extending past it — each release either closes a gap against the older package or adds a boundary type gsDesign never had. A visible second track is output plumbing: every new statistical feature now arrives already threaded through summary(), gs_bound_summary(), as_gt(), and as_rtf(), which is what regulatory submission work actually consumes. Performance work is steady but secondary, with gs_design_ahr() roughly 2x faster in 1.1.9.

◆ Prediction

Expect the harm boundary work to propagate into the WLR and risk-difference design families, which are the two design branches 1.2.0 left untouched, along with a vignette bridging harm boundaries to the remaining gsDesign test types.

Holistics logo
Holistics
ANALYTICS
5.0

Holistics is adding governance to the AI layer it spent the summer building.

◆ Current state

Holistics ships small, frequent notes - often one or two sentences - covering three strands at once: AI features in Explore and Chat, as-code control over presentation through AML, and workspace hygiene like file history and dark mode. The August entries turn to the AI layer's edges rather than its capabilities, with an AI user attribute for restricting what the assistant can reach. Several entries are barely a line long, so scope frequently has to be read from the headline.

◆ Where it's heading

The AI work has moved through a recognizable sequence: capability first with chart suggestions, then observability with AI Chat Insights for admins, and now access control with an AI-specific user attribute. Alongside it, Holistics keeps pulling presentation into AML - custom charts, theme palettes, currency formats - so the things analysts used to click are versioned as code. File history is the join between the two threads, giving every dashboard, model, and dataset its own restorable timeline.

◆ Prediction

With capability, visibility, and access control now in place for the AI layer, the next step is likely audit or policy depth - logging what the assistant answered against which data - rather than new AI surfaces.

Alternatives to gsDesign2 and Holistics

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either gsDesign2 or Holistics.

See all gsDesign2 alternatives → · See all Holistics alternatives →

Recent activity from gsDesign2 and Holistics

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 2d agoHolisticsAI user attribute restricts AI access to sensitive data
  2. 13d agogsDesign2Harm boundaries land in AHR and NPE group sequential designs
  3. 16d agoHolisticsCustom currency and unit formats, per field
  4. 19d agoHolisticsFile history: per-file version timeline and restore
  5. 22d agoHolisticsCustom charts become AML code with GUI authoring
  6. 23d agoHolisticsColor palettes can be assigned at the theme level
  7. 27d agoHolisticsDate-range presets and typed shorthands
  8. 1mo agogsDesign2Conditional power, sequential p-values, and minimal risk weighting
  9. 6mo agogsDesign2gs_design_ahr() can output spending time
  10. 9mo agogsDesign2S3 class refactor and futility boundary vignette
  11. 11mo agogsDesign2h1_spending for WLR power, info_scale across fixed designs
  12. 1y agogsDesign2WLR design spending default corrected to information fraction

Frequently asked questions

What is the difference between gsDesign2 and Holistics?

They serve adjacent needs but don't currently overlap on shipped themes. Holistics is currently shipping more aggressively (velocity 5.0 vs 3.8), with 0 editorial sparks in the last 30 days against 1. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is gsDesign2 better than Holistics?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. Holistics is currently shipping more aggressively (velocity 5.0 vs 3.8), with 0 editorial sparks in the last 30 days against 1. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to gsDesign2?

Top gsDesign2 alternatives in Analytics are ranked by recent ship velocity. Browse the "gsDesign2 alternatives" section above for the current picks, or visit /alternatives/gsdesign2 for the full list with editorial commentary on each.

What are the best alternatives to Holistics?

Top Holistics alternatives in Analytics are ranked by recent ship velocity. Browse the "Holistics alternatives" section above for the current picks, or visit /alternatives/holistics for the full list with editorial commentary on each.