gps2gtfs
gps2gtfs spent a release making its docs stop describing functions it does not have.
Comparison · Analytics
glyenzy vs pedFamilias
A side-by-side editorial comparison of glyenzy and pedFamilias — release velocity, themes, recent moves, and the top alternatives to consider.
glyenzy vs pedFamilias: at a glance
What is glyenzy?
Glycan biosynthesis as a traceable enzyme graph, now including sulfation and gaps it can bridge.
glyenzy infers which enzymes could have produced a glycan and traces biosynthetic routes to it, backed by curated per-enzyme rules for human glycosyltransferases and, since 0.7.0, twelve sulfotransferases. Biosynthesis functions return typed network objects that keep their igraph interface while supporting layered DAG plots with glycan nodes and labelled enzyme edges. Where no concrete enzyme covers a step, bounded virtual transitions bridge the gap and are marked so users can see which edges are inferred rather than enzymatic.
What is pedFamilias?
pedFamilias exists to read one legacy file format, and it has that job nearly finished.
pedFamilias holds the Familias file interoperability code that was split out of forrel, principally readFam() and writeFam(). The visible history is short and narrow: URL paths accepted as input, a deduplicate option for files produced by the Familias DVI module, better handling of extra individuals, and a fallback mutation model when stabilization fails. The most recent release is explicitly maintenance.
glyenzy vs pedFamilias: editorial side-by-side
glyenzy
6.3ANALYTICS
Glycan biosynthesis as a traceable enzyme graph, now including sulfation and gaps it can bridge.
◆ Current state
glyenzy infers which enzymes could have produced a glycan and traces biosynthetic routes to it, backed by curated per-enzyme rules for human glycosyltransferases and, since 0.7.0, twelve sulfotransferases. Biosynthesis functions return typed network objects that keep their igraph interface while supporting layered DAG plots with glycan nodes and labelled enzyme edges. Where no concrete enzyme covers a step, bounded virtual transitions bridge the gap and are marked so users can see which edges are inferred rather than enzymatic.
◆ Where it's heading
Two kinds of release alternate here. One is enzyme curation, a steady stream of rule corrections for the FUT, MAN1A and MGAT families and removals where an enzyme turned out to act only on glycolipids, which is the unglamorous accuracy work a rule-based inference engine lives on. The other is turning biosynthesis output into a first-class object: paths became networks, networks became typed with plotting support, and targets became a marked vertex attribute. The package moves in lockstep with its siblings, pinning glyrepr 0.13.0 and glymotif 0.17.0 as those refreshed their data and matching APIs, and the latest release already speaks glydraw 0.8.0's orientation values.
◆ Prediction
The paucimannose N-glycan support dropped in 0.7.0 is the obvious loose end, with users told to stay on 0.6.3, so a reinstated implementation is a plausible next move. Beyond that the virtual-step machinery is new enough that its heuristics, particularly the inferred step limits added in 0.8.1, should keep being tuned.
pedFamilias
0.0ANALYTICS
pedFamilias exists to read one legacy file format, and it has that job nearly finished.
◆ Current state
pedFamilias holds the Familias file interoperability code that was split out of forrel, principally readFam() and writeFam(). The visible history is short and narrow: URL paths accepted as input, a deduplicate option for files produced by the Familias DVI module, better handling of extra individuals, and a fallback mutation model when stabilization fails. The most recent release is explicitly maintenance.
◆ Where it's heading
This is a package with a bounded remit. The format it parses does not change, so releases arrive only when someone encounters a file it mishandles, and the fixes are correspondingly specific. The interesting movement is upstream instead: forrel finally removed its deprecated readFam() re-export in 1.9.0, completing the split that created this package.
◆ Prediction
Expect continued low-frequency maintenance driven by real-world .fam files rather than any planned feature work.
Alternatives to glyenzy and pedFamilias
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either glyenzy or pedFamilias.
ducksemantics
ducksemantics puts an ontology graph and ColBERT retrieval inside DuckDB, callable from R.
dvir
dvir keeps making disaster victim identification a single call instead of a workflow.
pedbuildr
pedbuildr reconstructs pedigrees from DNA, and it just got much faster at the search.
forrel
forrel is getting faster at the simulations forensic kinship work actually spends its time on.
pedmut
pedmut turns awkward mutation models into ones the likelihood engine can actually handle.
See all glyenzy alternatives → · See all pedFamilias alternatives →
Recent activity from glyenzy and pedFamilias
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 14d agoglyenzyStep limits inferred from the target glycan; MGAT4 and MGAT5 rules updated
- 17d agoglyenzyBiosynthesis results become typed network objects with layered DAG plots
- 23d agoglyenzySulfotransferases become first-class, and unsupported steps can be bridged ⚡
- 1mo agoglyenzyCompatibility with glymotif 0.17.0 and later
- 1mo agoglyenzyEnzyme data refreshed against glyrepr 0.13.0 structure data
- 1mo agoglyenzyCorrected rules for the MAN1A1, MAN1A2 and MAN1C1 mannosidases
- 2mo agopedFamiliasMaintenance release
- 1y agopedFamiliasreadFam() accepts URLs
- 2y agopedFamiliasExtra-individual parsing and mutation model fallback
- 2y agopedFamiliasdeduplicate option for Familias DVI files
Frequently asked questions
What is the difference between glyenzy and pedFamilias?
They serve adjacent needs but don't currently overlap on shipped themes. glyenzy is currently shipping more aggressively (velocity 6.3 vs 0.0), with 1 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is glyenzy better than pedFamilias?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. glyenzy is currently shipping more aggressively (velocity 6.3 vs 0.0), with 1 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to glyenzy?
Top glyenzy alternatives in Analytics are ranked by recent ship velocity. Browse the "glyenzy alternatives" section above for the current picks, or visit /alternatives/glyenzy for the full list with editorial commentary on each.
What are the best alternatives to pedFamilias?
Top pedFamilias alternatives in Analytics are ranked by recent ship velocity. Browse the "pedFamilias alternatives" section above for the current picks, or visit /alternatives/pedfamilias for the full list with editorial commentary on each.