gps2gtfs
gps2gtfs spent a release making its docs stop describing functions it does not have.
Comparison · Analytics
glyenzy vs pedbuildr
A side-by-side editorial comparison of glyenzy and pedbuildr — release velocity, themes, recent moves, and the top alternatives to consider.
glyenzy vs pedbuildr: at a glance
What is glyenzy?
Glycan biosynthesis as a traceable enzyme graph, now including sulfation and gaps it can bridge.
glyenzy infers which enzymes could have produced a glycan and traces biosynthetic routes to it, backed by curated per-enzyme rules for human glycosyltransferases and, since 0.7.0, twelve sulfotransferases. Biosynthesis functions return typed network objects that keep their igraph interface while supporting layered DAG plots with glycan nodes and labelled enzyme edges. Where no concrete enzyme covers a step, bounded virtual transitions bridge the gap and are marked so users can see which edges are inferred rather than enzymatic.
What is pedbuildr?
pedbuildr reconstructs pedigrees from DNA, and it just got much faster at the search.
pedbuildr infers pedigree structure from marker data by scoring candidate pedigrees against likelihoods. Version 0.4.0 moved reconstruct() to mirai for parallel likelihood computation, deprecated the old numCores argument, and picked up the improved loop breaking from pedtools and pedprobr, which lets many complex looped pedigrees succeed where they previously failed. buildPeds() also got significantly faster in its default configuration where mating between lineally related individuals is disallowed.
glyenzy vs pedbuildr: editorial side-by-side
glyenzy
6.3ANALYTICS
Glycan biosynthesis as a traceable enzyme graph, now including sulfation and gaps it can bridge.
◆ Current state
glyenzy infers which enzymes could have produced a glycan and traces biosynthetic routes to it, backed by curated per-enzyme rules for human glycosyltransferases and, since 0.7.0, twelve sulfotransferases. Biosynthesis functions return typed network objects that keep their igraph interface while supporting layered DAG plots with glycan nodes and labelled enzyme edges. Where no concrete enzyme covers a step, bounded virtual transitions bridge the gap and are marked so users can see which edges are inferred rather than enzymatic.
◆ Where it's heading
Two kinds of release alternate here. One is enzyme curation, a steady stream of rule corrections for the FUT, MAN1A and MGAT families and removals where an enzyme turned out to act only on glycolipids, which is the unglamorous accuracy work a rule-based inference engine lives on. The other is turning biosynthesis output into a first-class object: paths became networks, networks became typed with plotting support, and targets became a marked vertex attribute. The package moves in lockstep with its siblings, pinning glyrepr 0.13.0 and glymotif 0.17.0 as those refreshed their data and matching APIs, and the latest release already speaks glydraw 0.8.0's orientation values.
◆ Prediction
The paucimannose N-glycan support dropped in 0.7.0 is the obvious loose end, with users told to stay on 0.6.3, so a reinstated implementation is a plausible next move. Beyond that the virtual-step machinery is new enough that its heuristics, particularly the inferred step limits added in 0.8.1, should keep being tuned.
pedbuildr
0.0ANALYTICS
pedbuildr reconstructs pedigrees from DNA, and it just got much faster at the search.
◆ Current state
pedbuildr infers pedigree structure from marker data by scoring candidate pedigrees against likelihoods. Version 0.4.0 moved reconstruct() to mirai for parallel likelihood computation, deprecated the old numCores argument, and picked up the improved loop breaking from pedtools and pedprobr, which lets many complex looped pedigrees succeed where they previously failed. buildPeds() also got significantly faster in its default configuration where mating between lineally related individuals is disallowed.
◆ Where it's heading
The package is bounded by two costs: how many candidate pedigrees it enumerates and how expensive each likelihood is. The recent release attacks both, parallelizing the likelihoods and speeding up enumeration in the common case. The earlier 0.3.0 release worked on the other end, adding inbreeding limits and a proper result class so the output of a large search is manageable. Releases are infrequent, roughly three years apart in this window.
◆ Prediction
Expect the candidate generation side to receive the same attention the likelihood side just did, since search space size is the remaining bound on what pedbuildr can reconstruct.
Alternatives to glyenzy and pedbuildr
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either glyenzy or pedbuildr.
ducksemantics
ducksemantics puts an ontology graph and ColBERT retrieval inside DuckDB, callable from R.
dvir
dvir keeps making disaster victim identification a single call instead of a workflow.
forrel
forrel is getting faster at the simulations forensic kinship work actually spends its time on.
pedFamilias
pedFamilias exists to read one legacy file format, and it has that job nearly finished.
pedmut
pedmut turns awkward mutation models into ones the likelihood engine can actually handle.
See all glyenzy alternatives → · See all pedbuildr alternatives →
Recent activity from glyenzy and pedbuildr
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 14d agoglyenzyStep limits inferred from the target glycan; MGAT4 and MGAT5 rules updated
- 17d agoglyenzyBiosynthesis results become typed network objects with layered DAG plots
- 23d agoglyenzySulfotransferases become first-class, and unsupported steps can be bridged ⚡
- 1mo agoglyenzyCompatibility with glymotif 0.17.0 and later
- 1mo agoglyenzyEnzyme data refreshed against glyrepr 0.13.0 structure data
- 1mo agopedbuildrmirai parallelism and faster pedigree enumeration
- 1mo agoglyenzyCorrected rules for the MAN1A1, MAN1A2 and MAN1C1 mannosidases
- 2y agopedbuildrpedCollection class and an inbreeding ceiling
Frequently asked questions
What is the difference between glyenzy and pedbuildr?
They serve adjacent needs but don't currently overlap on shipped themes. glyenzy is currently shipping more aggressively (velocity 6.3 vs 0.0), with 1 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is glyenzy better than pedbuildr?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. glyenzy is currently shipping more aggressively (velocity 6.3 vs 0.0), with 1 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to glyenzy?
Top glyenzy alternatives in Analytics are ranked by recent ship velocity. Browse the "glyenzy alternatives" section above for the current picks, or visit /alternatives/glyenzy for the full list with editorial commentary on each.
What are the best alternatives to pedbuildr?
Top pedbuildr alternatives in Analytics are ranked by recent ship velocity. Browse the "pedbuildr alternatives" section above for the current picks, or visit /alternatives/pedbuildr for the full list with editorial commentary on each.