STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
GeneNMF vs spEDM
A side-by-side editorial comparison of GeneNMF and spEDM — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
GeneNMF vs spEDM: at a glance
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
What is spEDM?
Spatial causal discovery in R, one exposed method per release
spEDM brings empirical dynamic modeling to spatial data — cross mapping, convergent cross mapping and pattern causality over spatial vector and raster inputs, with the numerics in C++ behind S4 generics. The recent releases have exposed geographical pattern causality and spatially convergent partial cross mapping at the R level with vignettes, and 1.12 turns to consolidating the API. It is part of the stscl family alongside the temporal-domain tEDM, with which it shares both its C++ core and its maintainer.
GeneNMF vs spEDM: editorial side-by-side
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
spEDM
0.0ANALYTICS
Spatial causal discovery in R, one exposed method per release
◆ Current state
spEDM brings empirical dynamic modeling to spatial data — cross mapping, convergent cross mapping and pattern causality over spatial vector and raster inputs, with the numerics in C++ behind S4 generics. The recent releases have exposed geographical pattern causality and spatially convergent partial cross mapping at the R level with vignettes, and 1.12 turns to consolidating the API. It is part of the stscl family alongside the temporal-domain tEDM, with which it shares both its C++ core and its maintainer.
◆ Where it's heading
The cadence is steady and predictable: each release surfaces one more EDM method as an R-level API with a vignette, then spends the rest of its notes on parameter-handling consistency across the generics. Breaking changes are frequent and deliberate — argument renames, parameter reordering, NA-handling defaults — which reads as a package still settling its interface while the method surface expands. Shared changes appear in tEDM within days, so interface churn lands on both packages at once.
◆ Prediction
Expect the next release to expose another causality variant at the R level with an accompanying vignette, and to continue renaming or reordering parameters toward consistency across the spatial and temporal packages.
Alternatives to GeneNMF and spEDM
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either GeneNMF or spEDM.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all GeneNMF alternatives → · See all spEDM alternatives →
Recent activity from GeneNMF and spEDM
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 4mo agospEDMData slicing for large-scale pattern causality, plus API breaks
- 6mo agospEDMspEDM 1.11
- 6mo agospEDMSpatially convergent partial cross mapping reaches the R API
- 8mo agospEDMRaster cross mapping with anisotropic embedding
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 11mo agospEDMConfigurable distance metrics and multithreaded distance computation
- 1y agospEDMSpatial logistic map exposed at the R level
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
Frequently asked questions
What is the difference between GeneNMF and spEDM?
Both compete on the same themes — r-package — within Analytics. GeneNMF and spEDM are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is GeneNMF better than spEDM?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. GeneNMF and spEDM are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.
What are the best alternatives to spEDM?
Top spEDM alternatives in Analytics are ranked by recent ship velocity. Browse the "spEDM alternatives" section above for the current picks, or visit /alternatives/spedm for the full list with editorial commentary on each.