STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
GeneNMF vs probmed
A side-by-side editorial comparison of GeneNMF and probmed — release velocity, themes, recent moves, and the top alternatives to consider.
GeneNMF vs probmed: at a glance
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
What is probmed?
probmed went from one probabilistic effect size to a family of them in sixteen days.
probmed computes P_med, a scale-free probabilistic effect size for causal mediation, as part of the Data-Wise mediationverse alongside medfit, medsim and RMediation. Three releases in three weeks took it from a single estimator to four additional families built on a shared cross-fitted corner-EIF core, covering gauge-calibrated, incremental-elasticity and Sobol variance-share versions of the proportion mediated. Distribution is GitHub and r-universe rather than CRAN, with a load-bearing Remotes pin on medfit.
GeneNMF vs probmed: editorial side-by-side
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
probmed
0.0ANALYTICS
probmed went from one probabilistic effect size to a family of them in sixteen days.
◆ Current state
probmed computes P_med, a scale-free probabilistic effect size for causal mediation, as part of the Data-Wise mediationverse alongside medfit, medsim and RMediation. Three releases in three weeks took it from a single estimator to four additional families built on a shared cross-fitted corner-EIF core, covering gauge-calibrated, incremental-elasticity and Sobol variance-share versions of the proportion mediated. Distribution is GitHub and r-universe rather than CRAN, with a load-bearing Remotes pin on medfit.
◆ Where it's heading
The pace is manuscript-driven — estimators arrive with their citations attached and vignettes alongside, and the 0.1.0 notes correct the estimand itself against a manuscript definition rather than fixing a bug in code. Each release adds inference machinery as well as point estimates: percentile-bootstrap intervals and Fieller sets in 0.3.0, a deterministic MBCO interval in 0.2.0 that avoids resampling entirely. The gauge residual and the pmed_sensitivity() helper suggest a growing concern with when the estimand does not decompose at all.
◆ Prediction
0.3.0 shipped a sensitivity helper for shared mediator-outcome confounding and a diagnostic that flags non-decomposability, so the next release most likely extends that diagnostic side rather than adding a fifth estimator family.
Alternatives to GeneNMF and probmed
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either GeneNMF or probmed.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all GeneNMF alternatives → · See all probmed alternatives →
Recent activity from GeneNMF and probmed
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoprobmedFour estimator families on a cross-fitted corner-EIF core ⚡
- 2mo agoprobmedParallel mediators and a resampling-free MBCO interval ⚡
- 2mo agoprobmedFirst release: pmed() with the estimand corrected
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
Frequently asked questions
What is the difference between GeneNMF and probmed?
They serve adjacent needs but don't currently overlap on shipped themes. GeneNMF and probmed are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is GeneNMF better than probmed?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. GeneNMF and probmed are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.
What are the best alternatives to probmed?
Top probmed alternatives in Analytics are ranked by recent ship velocity. Browse the "probmed alternatives" section above for the current picks, or visit /alternatives/probmed for the full list with editorial commentary on each.