STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
GeneNMF vs intsurv
A side-by-side editorial comparison of GeneNMF and intsurv — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
GeneNMF vs intsurv: at a glance
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
What is intsurv?
A Cox cure-rate model package woke up after four years to simplify its own interface.
intsurv fits Cox cure rate models for right-censored survival data where event status may be uncertain — the case where you cannot tell whether a subject experienced the event or was never susceptible to it. The core has been stable since 2019: cox_cure() and its regularized counterpart cox_cure_net(), plus a weighted concordance index and a data simulator. After more than four years without a release, version 0.3.0 arrived in September 2025 and restructured how those two functions are configured rather than adding capability.
GeneNMF vs intsurv: editorial side-by-side
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
intsurv
0.0ANALYTICS
A Cox cure-rate model package woke up after four years to simplify its own interface.
◆ Current state
intsurv fits Cox cure rate models for right-censored survival data where event status may be uncertain — the case where you cannot tell whether a subject experienced the event or was never susceptible to it. The core has been stable since 2019: cox_cure() and its regularized counterpart cox_cure_net(), plus a weighted concordance index and a data simulator. After more than four years without a release, version 0.3.0 arrived in September 2025 and restructured how those two functions are configured rather than adding capability.
◆ Where it's heading
The package has reached the point where the methods are settled and the remaining work is ergonomics. Moving control parameters, M-step settings and penalty specification into cox_cure.control(), cox_cure.mstep() and cox_cure_net.penalty() follows the established R convention of separating tuning from the model formula, and it arrives long after the arguments accumulated. The C++ headers were placed in inst/include as early as 2019 so other packages could link against them, which suggests the implementation was always intended to be reused.
◆ Prediction
The gap between 0.2.2 and 0.3.0 makes cadence a poor basis for prediction. What the entries do support is that the interface rework is unfinished business rather than a prelude to new methods, so consolidation around the new helper functions is the likelier next step.
Alternatives to GeneNMF and intsurv
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either GeneNMF or intsurv.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all GeneNMF alternatives → · See all intsurv alternatives →
Recent activity from GeneNMF and intsurv
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 10mo agointsurvModel configuration moves into dedicated control functions
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
- 5y agointsurvCross-validated model selection and offset terms added
- 6y agointsurvC++ headers relocated so other packages can link them
- 7y agointsurvCox cure models for uncertain event status arrive
- 7y agointsurvParameter initialization methods added to the alpha
- 7y agointsurvAlpha cut for paper submission and simulation reproducibility
Frequently asked questions
What is the difference between GeneNMF and intsurv?
Both compete on the same themes — r-package — within Analytics. GeneNMF and intsurv are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is GeneNMF better than intsurv?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. GeneNMF and intsurv are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.
What are the best alternatives to intsurv?
Top intsurv alternatives in Analytics are ranked by recent ship velocity. Browse the "intsurv alternatives" section above for the current picks, or visit /alternatives/intsurv for the full list with editorial commentary on each.