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Comparison · Analytics
distributions3 vs TwoSampleMR
A side-by-side editorial comparison of distributions3 and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
distributions3 vs TwoSampleMR: at a glance
| Feature | distributions3 | TwoSampleMR |
|---|---|---|
| Sector | Analytics | Analytics |
| Velocity score | 6.3 | 0.0 |
| Sparks · 30d | 1 | 0 |
| Top themes | r-package, probability-distributions, empirical-distributions, likelihood-inference | mendelian-randomization, genetic-epidemiology, correctness-fixes, opengwas |
| Last editorial update | 1h ago | 4d ago |
| Website | Visit → | Visit → |
What is distributions3?
distributions3 0.3.0 adds sample-based distributions and likelihood derivatives
An R package giving probability distributions a consistent object interface - d/p/q/r functions, moments, and prodist() methods that pull a fitted distribution out of a regression object. Version 0.3.0 is the first substantive release under Achim Zeileis's maintenance, and it widens what a distribution is allowed to be: Empirical() represents a distribution by a random sample rather than by parameters, and numerical fallbacks now fill in cdf(), pdf(), quantile(), random() and the moments for any object that implements only some of them. New score() and hessian() generics compute first and second derivatives of the log-likelihood with respect to the parameters, analytically for a few distributions and numerically for the rest.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
distributions3 vs TwoSampleMR: editorial side-by-side
distributions3
6.3ANALYTICS
distributions3 0.3.0 adds sample-based distributions and likelihood derivatives
◆ Current state
An R package giving probability distributions a consistent object interface - d/p/q/r functions, moments, and prodist() methods that pull a fitted distribution out of a regression object. Version 0.3.0 is the first substantive release under Achim Zeileis's maintenance, and it widens what a distribution is allowed to be: Empirical() represents a distribution by a random sample rather than by parameters, and numerical fallbacks now fill in cdf(), pdf(), quantile(), random() and the moments for any object that implements only some of them. New score() and hessian() generics compute first and second derivatives of the log-likelihood with respect to the parameters, analytically for a few distributions and numerically for the rest.
◆ Where it's heading
Growth used to arrive as new distribution families contributed from outside - the extreme-value set, Erlang, later the Poisson binomial. This release changes the axis: alongside two new distributions it adds an inference layer (score, hessian) and a forecast-evaluation one (crps() methods against scoringRules), which are capabilities about distributions rather than more of them. Dependency weight is being cut at the same time, with ggplot2 demoted to Suggests and glue replaced by base R sprintf().
◆ Prediction
With numeric fallbacks and the derivative generics in place, expect analytic score() and hessian() methods to be filled in across more of the distribution catalogue. The constructor-default change is the likeliest source of follow-up fixes, since calls like Poisson() now return a length-zero distribution where they previously errored.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to distributions3 and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either distributions3 or TwoSampleMR.
RStudio
RStudio ships through release branches, and the notes are commit messages
dbt Core
dbt Fusion's second beta is adapter work: ClickHouse gets materializations, indexes, and catalogs
Fulcrum
Fulcrum is betting its whole map stack on Esri, with a hard Google Maps cutoff on September 1.
Holistics
Holistics keeps fencing in the AI layer it spent the summer building.
Dovetail
Dovetail spent July opening doors to other tools and August making its own rooms easier to enter.
See all distributions3 alternatives → · See all TwoSampleMR alternatives →
Recent activity from distributions3 and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1h agodistributions3Empirical distributions, plus score and hessian generics ⚡
- 28d agodistributions3Maintenance moves to Achim Zeileis; moment calculations corrected
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 10mo agodistributions3ggplot2 compatibility for the plotting functions
- 1y agodistributions3Poisson binomial distribution, with a normal-approximation fallback
- 3y agodistributions3is_discrete and is_continuous generics, plus elementwise type-safety
- 4y agodistributions3Extreme-value family, Erlang, and a plotting generic
Frequently asked questions
What is the difference between distributions3 and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. distributions3 is currently shipping more aggressively (velocity 6.3 vs 0.0), with 1 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is distributions3 better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. distributions3 is currently shipping more aggressively (velocity 6.3 vs 0.0), with 1 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to distributions3?
Top distributions3 alternatives in Analytics are ranked by recent ship velocity. Browse the "distributions3 alternatives" section above for the current picks, or visit /alternatives/distributions3-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.