STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
discretefdr vs GeneNMF
A side-by-side editorial comparison of discretefdr and GeneNMF — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
discretefdr vs GeneNMF: at a glance
What is discretefdr?
The discrete-data FDR package is being pared into one piece of a larger multiple-testing suite.
DiscreteFDR implements false discovery rate procedures adapted for discrete test statistics, where the standard continuous-case corrections are conservative. It now covers a discrete Benjamini-Yekutieli procedure alongside the Benjamini-Hochberg variants it started with, including adaptive versions. Its datasets and test-result classes have been moved out into companion packages, so it increasingly does one job and defers the rest.
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
discretefdr vs GeneNMF: editorial side-by-side
discretefdr
0.0ANALYTICS
The discrete-data FDR package is being pared into one piece of a larger multiple-testing suite.
◆ Current state
DiscreteFDR implements false discovery rate procedures adapted for discrete test statistics, where the standard continuous-case corrections are conservative. It now covers a discrete Benjamini-Yekutieli procedure alongside the Benjamini-Hochberg variants it started with, including adaptive versions. Its datasets and test-result classes have been moved out into companion packages, so it increasingly does one job and defers the rest.
◆ Where it's heading
The direction is decomposition into a suite. The amnesia dataset went to DiscreteDatasets, summary output now interoperates with the DiscreteTestResults class from DiscreteTests, and match.pvals() stopped being exported — each release trims something that belongs elsewhere. What remains gets methodological additions at a slow, deliberate cadence, with performance work on the step-up procedures that dominate cost when the number of tests is large. Recent activity is maintenance: replacing deprecated calls the package still made of its own siblings. This is a mature statistical package whose release notes are short because the methods underneath them are settled.
◆ Prediction
Expect further alignment with the companion packages rather than new procedures, since the last substantive release was already about interoperating with DiscreteTests classes and the most recent one about clearing deprecations.
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
Alternatives to discretefdr and GeneNMF
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either discretefdr or GeneNMF.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all discretefdr alternatives → · See all GeneNMF alternatives →
Recent activity from discretefdr and GeneNMF
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 3mo agodiscretefdrDeprecated internal calls replaced
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agodiscretefdrDiscrete Benjamini-Yekutieli procedure added
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 1y agodiscretefdrDatasets split out and step-up procedures sped up
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
Frequently asked questions
What is the difference between discretefdr and GeneNMF?
Both compete on the same themes — r-package — within Analytics. discretefdr and GeneNMF are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is discretefdr better than GeneNMF?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. discretefdr and GeneNMF are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to discretefdr?
Top discretefdr alternatives in Analytics are ranked by recent ship velocity. Browse the "discretefdr alternatives" section above for the current picks, or visit /alternatives/discretefdr for the full list with editorial commentary on each.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.