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Comparison · Analytics
affiner vs TwoSampleMR
A side-by-side editorial comparison of affiner and TwoSampleMR — release velocity, themes, recent moves, and the top alternatives to consider.
affiner vs TwoSampleMR: at a glance
What is affiner?
affiner is quietly turning a grid transformation helper into a small computational geometry library.
An R package that began as a wrapper around grid's affine transformation primitives, with an angle vector class supporting degrees, radians, half-turns, turns and gradians so users need not convert by hand. Four releases in roughly eighteen months. The recent two have expanded well past that starting point into geometric objects and the predicates that operate on them.
What is TwoSampleMR?
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
affiner vs TwoSampleMR: editorial side-by-side
affiner
0.0ANALYTICS
affiner is quietly turning a grid transformation helper into a small computational geometry library.
◆ Current state
An R package that began as a wrapper around grid's affine transformation primitives, with an angle vector class supporting degrees, radians, half-turns, turns and gradians so users need not convert by hand. Four releases in roughly eighteen months. The recent two have expanded well past that starting point into geometric objects and the predicates that operate on them.
◆ Where it's heading
The direction is clear from the order things arrived. Version 0.2.1 added the predicate layer first — has_intersection(), intersection(), is_equivalent() and is_parallel() as S3 generics working across angle vectors, points, lines and planes. Version 0.3.1 then supplied the objects those generics need, with Ellipse2D, Polygon2D and Segment2D R6 classes plus constructors for rectangles, regular n-gons and isotoxal star polygons, and dot products at one, two and three dimensions. Building the operations before the shapes is unusual ordering but it means each new object type arrives already composable with everything else.
◆ Prediction
Expect more 2D and 3D object types filling out the same generic interface, and the geometry side to keep outgrowing the grid-transformation wrapper the package was named for.
TwoSampleMR
0.0ANALYTICS
The flagship Mendelian randomization package is auditing its own estimators, one bootstrap at a time.
◆ Current state
TwoSampleMR is the MRC-IEU package for two-sample Mendelian randomization against OpenGWAS. Its 2026 releases are a sustained correctness review rather than feature work: 0.7.9 fixed bootstrap standard errors in mr_mode() and mr_rucker_bootstrap() that had been inflated since v0.6.30, and repaired two Rucker functions that were returning malformed objects. Point estimates were not affected by the bootstrap bug.
◆ Where it's heading
The pattern across these releases is a package being read line by line — a copy-paste weight vector in ldsc_rg(), chunking that produced zero splits for short SNP lists, penalisation recycled across the wrong SNPs, dead code paths removed, and regression tests added behind each fix. Alongside it runs a mechanical modernization pass: seq_len() for loop indices, tidyr in place of reshape2, current ggplot2 idioms, and the OpenGWAS URL migration. Feature work is limited to forest plot presentation.
◆ Prediction
Expect the audit to continue through the remaining bootstrap and jackknife routines, with releases staying in the 0.7.x patch range and each fix arriving with its own regression test.
Alternatives to affiner and TwoSampleMR
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either affiner or TwoSampleMR.
epiworldR
epiworldR is a thin R shell whose releases track the C++ simulator underneath it
watina
A groundwater database client that has started doing the domain analysis too
inbospatial
A thin R wrapper over Flemish geospatial services, adding one standard at a time
Fluent Bit
Fluent Bit keeps two lines alive while the 5.x branch quietly opens 5.1.
OpenCTI
OpenCTI is rebuilding its connector layer into a marketplace and wiring the platform to XTM Hub
See all affiner alternatives → · See all TwoSampleMR alternatives →
Recent activity from affiner and TwoSampleMR
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoTwoSampleMRBootstrap standard errors corrected in mode and Rucker estimators
- 2mo agoTwoSampleMRWrong weight vector and chunking fixes across the estimator set
- 2mo agoTwoSampleMRDeprecated ggplot2 idioms and dead code removed
- 3mo agoaffinerEllipse, polygon and segment objects, with star and n-gon constructors
- 3mo agoTwoSampleMROpenGWAS URLs migrated and Wald ratio warnings quieted
- 4mo agoTwoSampleMRCategorized forest plots aligned with the published figures
- 4mo agoTwoSampleMRFurther internal code optimizations
- 6mo agoaffinerIntersection, equivalence and parallelism generics across geometric types
- 1y agoaffinerIsocube border fill forced transparent
- 1y agoaffinerInitial release: affine grob wrappers and multi-unit angle vectors
Frequently asked questions
What is the difference between affiner and TwoSampleMR?
They serve adjacent needs but don't currently overlap on shipped themes. affiner and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is affiner better than TwoSampleMR?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. affiner and TwoSampleMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to affiner?
Top affiner alternatives in Analytics are ranked by recent ship velocity. Browse the "affiner alternatives" section above for the current picks, or visit /alternatives/affiner-r for the full list with editorial commentary on each.
What are the best alternatives to TwoSampleMR?
Top TwoSampleMR alternatives in Analytics are ranked by recent ship velocity. Browse the "TwoSampleMR alternatives" section above for the current picks, or visit /alternatives/twosamplemr for the full list with editorial commentary on each.