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Comparison · Analytics

simtrial vs tern

A side-by-side editorial comparison of simtrial and tern — release velocity, themes, recent moves, and the top alternatives to consider.

Shared themes:clinical-trialspharmaverse

simtrial vs tern: at a glance

Featuresimtrialtern
SectorAnalyticsAnalytics
Velocity score0.00.0
Sparks · 30d00
Top themesclinical-trials, group-sequential, survival-analysis, simulationclinical-trials, tables, r-package, pharmaverse
Last editorial update1h ago57m ago
WebsiteVisit →Visit →

What is simtrial?

A fixed-design trial simulator grew a pluggable test framework, then spent a year proving the numbers

simtrial simulates time-to-event clinical trials and applies the tests used to analyse them — logrank, weighted logrank, MaxCombo, RMST, milestone. The 0.4.0 release turned it from a fixed-sample simulator into a group sequential one and standardised every test behind a common output contract, and the releases since have been about making that machinery correct and fast enough to run at scale. Version 1.0.0 arrived in June 2025 with the API settled and three vignettes explaining both the one-call and build-it-yourself paths.

Read the full simtrial trajectory →

What is tern?

tern is migrating its entire analysis-function catalogue off make_afun(), one release at a time.

tern builds the clinical-trial tables, listings, and graphs layer on top of rtables — occurrence counts, survival summaries, ANCOVA, incidence rates, subgroup and biomarker tabulations. The visible work across the window is a systematic refactor: dozens of analysis functions rewritten to drop make_afun() and adopt a common analysis-function style driven by rtables' additional_fun_params. Feature additions ride along with it.

Read the full tern trajectory →

simtrial vs tern: editorial side-by-side

S
simtrial
ANALYTICS
0.0

A fixed-design trial simulator grew a pluggable test framework, then spent a year proving the numbers

◆ Current state

simtrial simulates time-to-event clinical trials and applies the tests used to analyse them — logrank, weighted logrank, MaxCombo, RMST, milestone. The 0.4.0 release turned it from a fixed-sample simulator into a group sequential one and standardised every test behind a common output contract, and the releases since have been about making that machinery correct and fast enough to run at scale. Version 1.0.0 arrived in June 2025 with the API settled and three vignettes explaining both the one-call and build-it-yourself paths.

◆ Where it's heading

Post-1.0 the work is almost entirely statistical correctness and speed, and it is concentrated in sim_gs_n(): one-sided efficacy bounds, stratified targeted-event cut dates, a helper that derives cuttings straight from the design object. Performance moves in one direction throughout — dplyr replaced by data.table, foreach combination replaced by manual assembly, parallelisation added to sim_fixed_n() — because simulation-based operating characteristics are only useful if you can afford enough replications.

◆ Prediction

The recent fixes cluster on stratified and group sequential paths, so the next release most likely continues there rather than adding a new test type. The cut_from_design() helper suggests tighter coupling to gsDesign2 design objects is the direction of travel.

T
tern
ANALYTICS
0.0

tern is migrating its entire analysis-function catalogue off make_afun(), one release at a time.

◆ Current state

tern builds the clinical-trial tables, listings, and graphs layer on top of rtables — occurrence counts, survival summaries, ANCOVA, incidence rates, subgroup and biomarker tabulations. The visible work across the window is a systematic refactor: dozens of analysis functions rewritten to drop make_afun() and adopt a common analysis-function style driven by rtables' additional_fun_params. Feature additions ride along with it.

◆ Where it's heading

This is a multi-release architectural migration, not incremental polish. Each release converts another batch of functions, and the count is large — roughly two dozen in the most recent entry alone, after a comparable batch the release before. Alongside it, the denom parameter is being threaded through counting functions and g_lineplot is accumulating layout control, both patterns of standardising arguments that previously varied per function.

◆ Prediction

The refactor should continue until the make_afun() dependency is gone entirely, with the remaining tabulate_* and biomarker functions the likely next batch; the entries give no date for completion.

Alternatives to simtrial and tern

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either simtrial or tern.

See all simtrial alternatives → · See all tern alternatives →

Recent activity from simtrial and tern

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 8mo agosimtrialOne-sided efficacy bound and stratified cut date corrected
  2. 11mo agosimtrialsim_gs_n moved to data.table; stratified design example added
  3. 1y agosimtrial1.0.0 settles the wlr interface and documents both simulation paths
  4. 1y agoternTwo dozen more analysis functions drop make_afun()
  5. 1y agoterndenom threading, custom statistics, and compare_vars merged in
  6. 1y agosimtrialMilestone Z-score denominator corrected; parallel sim_fixed_n arrives
  7. 1y agoternRisk-difference columns for subgroup tables
  8. 2y agoterng_lineplot gains faceting and axis controls
  9. 2y agosimtrialChecks pass without Suggests dependencies
  10. 2y agosimtrialRMST and milestone tests, plus a user-definable cut and test framework

Frequently asked questions

What is the difference between simtrial and tern?

Both compete on the same themes — clinical-trials, pharmaverse — within Analytics. simtrial and tern are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is simtrial better than tern?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. simtrial and tern are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to simtrial?

Top simtrial alternatives in Analytics are ranked by recent ship velocity. Browse the "simtrial alternatives" section above for the current picks, or visit /alternatives/simtrial for the full list with editorial commentary on each.

What are the best alternatives to tern?

Top tern alternatives in Analytics are ranked by recent ship velocity. Browse the "tern alternatives" section above for the current picks, or visit /alternatives/tern for the full list with editorial commentary on each.