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Comparison · Infra & APIs
PEIMAN2 vs serocalculator
A side-by-side editorial comparison of PEIMAN2 and serocalculator — release velocity, themes, recent moves, and the top alternatives to consider.
PEIMAN2 vs serocalculator: at a glance
What is PEIMAN2?
PEIMAN2 cut its annotation database loose from its release cycle without breaking CRAN.
PEIMAN2 does enrichment analysis over post-translational modifications, testing whether a protein list is enriched for particular PTMs against UniProt-derived annotations, with translation functions bridging to mass spectrometry workflows. Its answers are only as current as its bundled database, and until June that database could only be refreshed by releasing a new package version. Version 1.1.0 changes that.
What is serocalculator?
A seroincidence engine grows up: whole API renamed, then clustered survey designs
serocalculator turns cross-sectional antibody measurements into infection-rate estimates, and it spent its last two releases making itself safe to depend on. Version 1.4.0 renamed nearly every user-facing function into a consistent est_seroincidence()/sr_params vocabulary; 1.4.1 shipped the migration crosswalk that admits how much that broke. The newest capability is cluster-robust variance estimation for household- and school-based surveys.
PEIMAN2 vs serocalculator: editorial side-by-side
PEIMAN2
0.0INFRA · APIS
PEIMAN2 cut its annotation database loose from its release cycle without breaking CRAN.
◆ Current state
PEIMAN2 does enrichment analysis over post-translational modifications, testing whether a protein list is enriched for particular PTMs against UniProt-derived annotations, with translation functions bridging to mass spectrometry workflows. Its answers are only as current as its bundled database, and until June that database could only be refreshed by releasing a new package version. Version 1.1.0 changes that.
◆ Where it's heading
The package has been moving from a fixed snapshot toward versioned, user-selectable data. Earlier releases updated the bundled database in place — 1.0.0 shipped the March 2025 version and said little else — which meant the annotation vintage was whatever the package version implied. Now update_peiman_database() downloads and caches external database files and UniProt PTM lists, enrichment workflows take a database_version argument, and the mass-spec translators take a ptmlist_version, so an analysis can pin a dated database rather than a package release. The CRAN-safe default is preserved deliberately: loading, examples and checks still use the bundled internal data and need no network.
◆ Prediction
Version pinning is now expressible but the release notes do not describe how a chosen version is recorded in output, so surfacing the active database version in results is the natural companion. The database and the UniProt PTM list are versioned separately, which leaves room for a combined manifest.
serocalculator
0.0INFRA · APIS
A seroincidence engine grows up: whole API renamed, then clustered survey designs
◆ Current state
serocalculator turns cross-sectional antibody measurements into infection-rate estimates, and it spent its last two releases making itself safe to depend on. Version 1.4.0 renamed nearly every user-facing function into a consistent est_seroincidence()/sr_params vocabulary; 1.4.1 shipped the migration crosswalk that admits how much that broke. The newest capability is cluster-robust variance estimation for household- and school-based surveys.
◆ Where it's heading
The arc runs from method to instrument. Early releases added example data and plotting; recent ones fix the API surface, satisfy CRAN's offline-failure policy, and extend the estimator to sampling designs field epidemiology actually uses — multi-level clustering, stratification, and the two combined. Each release also carries visible refactoring discipline (one function per file, linting, per-PR website previews) that reads like a package preparing for contributors it does not have yet.
◆ Prediction
With cluster_var and stratum_var now threaded through both est_seroincidence() and est_seroincidence_by(), survey weights are the remaining piece of a complex-survey design the sandwich estimator does not cover. The entries do not name it, so read that as direction rather than a promise.
Alternatives to PEIMAN2 and serocalculator
Other Infra & APIs products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either PEIMAN2 or serocalculator.
PINstimation
A market-microstructure toolkit that keeps adding estimators as the papers land.
nzilbb.vowels
A vowel-analysis package trimming dependencies after an email address got it archived.
emuR
The R half of the EMU speech database system, fixing what was quietly broken.
BAS
A Bayesian model-averaging package spending its 2.0 on memory, not methods.
tidyplots
tidyplots keeps rebuilding its own foundations rather than layering around them.
See all PEIMAN2 alternatives → · See all serocalculator alternatives →
Recent activity from PEIMAN2 and serocalculator
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 2mo agoPEIMAN2Database updates decouple from package releases ⚡
- 3mo agoserocalculatorCluster-robust standard errors for household and school surveys ⚡
- 7mo agoserocalculatorEvery estimation function renamed, plus a simulation-study workflow ⚡
- 1y agoPEIMAN2Bundled database refreshed to the March 2025 UniProt vintage
- 1y agoPEIMAN2Documentation fix for the second example dataset
- 1y agoserocalculatorBundled example datasets and a locator to find them
- 2y agoPEIMAN2Background lists for SEA and PSEA; tidyverse dependency dropped
Frequently asked questions
What is the difference between PEIMAN2 and serocalculator?
They serve adjacent needs but don't currently overlap on shipped themes. PEIMAN2 and serocalculator are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is PEIMAN2 better than serocalculator?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. PEIMAN2 and serocalculator are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Infra & APIs products to evaluate alongside.
What are the best alternatives to PEIMAN2?
Top PEIMAN2 alternatives in Infra & APIs are ranked by recent ship velocity. Browse the "PEIMAN2 alternatives" section above for the current picks, or visit /alternatives/peiman2 for the full list with editorial commentary on each.
What are the best alternatives to serocalculator?
Top serocalculator alternatives in Infra & APIs are ranked by recent ship velocity. Browse the "serocalculator alternatives" section above for the current picks, or visit /alternatives/serocalculator for the full list with editorial commentary on each.