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n1qn1c vs RadialMR

A side-by-side editorial comparison of n1qn1c and RadialMR — release velocity, themes, recent moves, and the top alternatives to consider.

Shared themes:r-package

n1qn1c vs RadialMR: at a glance

Featuren1qn1cRadialMR
SectorAnalyticsAnalytics
Velocity score0.00.0
Sparks · 30d00
Top themesnumerical-optimization, quasi-newton, thread-safety, memory-safetymendelian-randomization, radial-plots, correctness-audit, statistical-inference
Last editorial update1h ago1h ago
WebsiteVisit →Visit →

What is n1qn1c?

A Fortran-descended optimizer got thread-safe, then found two flags that never worked.

n1qn1c is a quasi-Newton optimization routine translated from Fortran to C, used as a solver backend by the nlmixr2 modeling stack rather than called directly by most users. Its two 2026 releases are a concentrated safety pass: global state converted to thread_local, static removed from local variables in the translated code, integer overflow guards added, and memory leaks closed in the R callback wrappers — plus the gcc-asan and valgrind fixes CRAN asked for.

Read the full n1qn1c trajectory →

What is RadialMR?

RadialMR's 2026 release corrects degrees of freedom that had been wrong since documentation.

RadialMR implements radial-plot formulations of IVW and MR-Egger Mendelian randomization, with outlier detection and interactive plotting. The recent history is thin on features and increasingly focused on the arithmetic: 1.2.4 in July 2026 fixes the degrees of freedom returned by egger_radial() to the documented n-2, corrects the heterogeneity p-value that inherited the same error, and repairs a negated lower bound in the random-effects bootstrap standard error search interval in ivw_radial().

Read the full RadialMR trajectory →

n1qn1c vs RadialMR: editorial side-by-side

N
n1qn1c
ANALYTICS
0.0

A Fortran-descended optimizer got thread-safe, then found two flags that never worked.

◆ Current state

n1qn1c is a quasi-Newton optimization routine translated from Fortran to C, used as a solver backend by the nlmixr2 modeling stack rather than called directly by most users. Its two 2026 releases are a concentrated safety pass: global state converted to thread_local, static removed from local variables in the translated code, integer overflow guards added, and memory leaks closed in the R callback wrappers — plus the gcc-asan and valgrind fixes CRAN asked for.

◆ Where it's heading

The package is being hardened for use inside a parallel modeling framework rather than extended. The audit that produced the thread-safety work also surfaced two plain bugs in features users would have assumed worked: restart = TRUE left the mode at 2 instead of 3 because of a typo, and assign = TRUE referenced the wrong field name so the compressed Hessian was never written to the supplied environment. Earlier work points the same direction — the 6.0.1-12 function-pointer interface exists so nlmixr2est does not need resubmission when this package changes.

◆ Prediction

Expect further memory-safety and sanitizer work rather than algorithmic change; a Fortran-translated numerical core under CRAN's checking regime generates that kind of release indefinitely.

R
RadialMR
ANALYTICS
0.0

RadialMR's 2026 release corrects degrees of freedom that had been wrong since documentation.

◆ Current state

RadialMR implements radial-plot formulations of IVW and MR-Egger Mendelian randomization, with outlier detection and interactive plotting. The recent history is thin on features and increasingly focused on the arithmetic: 1.2.4 in July 2026 fixes the degrees of freedom returned by egger_radial() to the documented n-2, corrects the heterogeneity p-value that inherited the same error, and repairs a negated lower bound in the random-effects bootstrap standard error search interval in ivw_radial().

◆ Where it's heading

This is a package being read closely by its maintainer rather than extended. The 1.2.x line pairs statistical corrections with defensive hardening — an rmr_format class check so unformatted input fails with a clear message, and plotly_radial() dispatching on object class instead of counting list elements. Both are the kind of change made while auditing, not while building.

◆ Prediction

Expect the audit to continue into the remaining estimator internals and print methods rather than new radial variants; the entries show no feature work queued.

Alternatives to n1qn1c and RadialMR

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either n1qn1c or RadialMR.

See all n1qn1c alternatives → · See all RadialMR alternatives →

Recent activity from n1qn1c and RadialMR

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 1mo agoRadialMRegger_radial() degrees of freedom corrected to n-2
  2. 3mo agoRadialMRroxygen2 bumped; package-level helpfile added
  3. 4mo agon1qn1crestart and assign flags fixed; sanitizer issues cleared
  4. 4mo agon1qn1cGlobal state converted to thread_local
  5. 4mo agoRadialMRUnspecified codebase optimizations
  6. 1y agoRadialMRggplot2 v4 warning removed from plot_radial()
  7. 1y agon1qn1cFunction-pointer API decouples nlmixr2est releases

Frequently asked questions

What is the difference between n1qn1c and RadialMR?

Both compete on the same themes — r-package — within Analytics. n1qn1c and RadialMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is n1qn1c better than RadialMR?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. n1qn1c and RadialMR are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to n1qn1c?

Top n1qn1c alternatives in Analytics are ranked by recent ship velocity. Browse the "n1qn1c alternatives" section above for the current picks, or visit /alternatives/n1qn1c for the full list with editorial commentary on each.

What are the best alternatives to RadialMR?

Top RadialMR alternatives in Analytics are ranked by recent ship velocity. Browse the "RadialMR alternatives" section above for the current picks, or visit /alternatives/radialmr for the full list with editorial commentary on each.