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Comparison · Infra & APIs

mice vs PowerTOST

A side-by-side editorial comparison of mice and PowerTOST — release velocity, themes, recent moves, and the top alternatives to consider.

mice vs PowerTOST: at a glance

FeaturemicePowerTOST
SectorInfra & APIsInfra & APIs
Velocity score0.00.0
Sparks · 30d00
Top themesmissing-data, multiple-imputation, statistics, r-packagebioequivalence, sample-size, regulatory, pharmacometrics
Last editorial update59m ago22h ago
WebsiteVisit →Visit →

What is mice?

mice can finally predict, not just estimate, from multiply imputed data.

mice is the reference implementation of multiple imputation by chained equations, and the default answer to missing data in R. The releases here follow a consistent shape: one or two substantive additions per version, most contributed by outside authors, plus fixes to methods that have been in the package for years. The current 3.19.0 adds predict_mi(), which pools predictions across imputations under Rubin's rules and can return prediction intervals.

Read the full mice trajectory →

What is PowerTOST?

A bioequivalence sample-size workhorse whose news is which regulator it now covers

PowerTOST computes power and sample size for bioequivalence and its changelog reads as a record of regulatory divergence more than statistical development. Version 1.5-3 added the Gulf Co-operation Council as a regulator setting; 1.5-4 and 1.5-6 stripped 'FDA' out of the narrow-therapeutic-index function names once China's CDE began requiring the same evaluation. The most recent release, 1.5-7, is a single fix to how nvec() splits a total sample size across sequences.

Read the full PowerTOST trajectory →

mice vs PowerTOST: editorial side-by-side

M
mice
INFRA · APIS
0.0

mice can finally predict, not just estimate, from multiply imputed data.

◆ Current state

mice is the reference implementation of multiple imputation by chained equations, and the default answer to missing data in R. The releases here follow a consistent shape: one or two substantive additions per version, most contributed by outside authors, plus fixes to methods that have been in the package for years. The current 3.19.0 adds predict_mi(), which pools predictions across imputations under Rubin's rules and can return prediction intervals.

◆ Where it's heading

Two things are happening. The imputation method catalogue keeps widening — lasso variants, multivariate PMM, categorical PMM via canonical correlation — while the pooling side is being extended past its original purpose, first to synthetic data, now to predictions on held-out sets. That second thread points at predictive modelling workflows rather than the inferential ones mice was built for. Meanwhile the maintainers keep finding consequential old bugs: the augment() ordered-factor defect in 3.18.0 had been silently degrading ordinal imputations for years.

◆ Prediction

predict_mi() is framed around evaluating predictive performance on test sets, and the ignore argument added in 3.12.0 already exists to hold out rows from the imputation model. Expect the next work to join those up into a fuller train/test story for imputed data, since the pieces are now in place but not yet connected.

P
PowerTOST
INFRA · APIS
0.0

A bioequivalence sample-size workhorse whose news is which regulator it now covers

◆ Current state

PowerTOST computes power and sample size for bioequivalence and its changelog reads as a record of regulatory divergence more than statistical development. Version 1.5-3 added the Gulf Co-operation Council as a regulator setting; 1.5-4 and 1.5-6 stripped 'FDA' out of the narrow-therapeutic-index function names once China's CDE began requiring the same evaluation. The most recent release, 1.5-7, is a single fix to how nvec() splits a total sample size across sequences.

◆ Where it's heading

The package is in long maintenance with a widening regulatory surface: the statistical methods are settled, and releases arrive when an agency publishes a framework that can be expressed as a settings variant of an existing method. Function naming has been deliberately decoupled from any single agency, with the deprecated FDA-suffixed aliases carried for years before removal. Cadence has slowed to roughly one release every eighteen months.

◆ Prediction

The next release is most likely another regulator setting or a small fix; on the deprecation notice already given, the power.NTIDFDA()-style aliases are the obvious removal candidate.

Alternatives to mice and PowerTOST

Other Infra & APIs products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either mice or PowerTOST.

See all mice alternatives → · See all PowerTOST alternatives →

Recent activity from mice and PowerTOST

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 8mo agomicemice 3.19.0
  2. 10mo agoPowerTOSTFix for splitting total sample size across sequences
  3. 1y agomicemice 3.18.0
  4. 1y agomicemice 3.17.0
  5. 2y agoPowerTOSTNTID functions renamed off the FDA acronym; GCC guidance in vignettes
  6. 3y agomicemice 3.16.0
  7. 3y agomicemice 3.15.0
  8. 4y agoPowerTOSTpower.NTID() aliases added; FDA-suffixed names deprecated
  9. 4y agomicemice 3.14.0
  10. 5y agoPowerTOSTGulf Co-operation Council added as a regulator setting
  11. 5y agoPowerTOSTMaintenance release with vignette and documentation clarifications
  12. 5y agoPowerTOSTstringsAsFactors fix for older R in a vignette example

Frequently asked questions

What is the difference between mice and PowerTOST?

They serve adjacent needs but don't currently overlap on shipped themes. mice and PowerTOST are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is mice better than PowerTOST?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. mice and PowerTOST are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Infra & APIs products to evaluate alongside.

What are the best alternatives to mice?

Top mice alternatives in Infra & APIs are ranked by recent ship velocity. Browse the "mice alternatives" section above for the current picks, or visit /alternatives/mice for the full list with editorial commentary on each.

What are the best alternatives to PowerTOST?

Top PowerTOST alternatives in Infra & APIs are ranked by recent ship velocity. Browse the "PowerTOST alternatives" section above for the current picks, or visit /alternatives/powertost for the full list with editorial commentary on each.