glyfun
glyfun is three releases old and has spent all of them chasing glyexp's container change.
Comparison · Analytics
glyenzy vs vellumwidget
A side-by-side editorial comparison of glyenzy and vellumwidget — release velocity, themes, recent moves, and the top alternatives to consider.
glyenzy vs vellumwidget: at a glance
What is glyenzy?
Glycan biosynthesis as a traceable enzyme graph, now including sulfation and gaps it can bridge.
glyenzy infers which enzymes could have produced a glycan and traces biosynthetic routes to it, backed by curated per-enzyme rules for human glycosyltransferases and, since 0.7.0, twelve sulfotransferases. Biosynthesis functions return typed network objects that keep their igraph interface while supporting layered DAG plots with glycan nodes and labelled enzyme edges. Where no concrete enzyme covers a step, bounded virtual transitions bridge the gap and are marked so users can see which edges are inferred rather than enzymatic.
What is vellumwidget?
vellumwidget is dissolving its own API: interaction now lives in the plot spec, not the widget call.
vellumwidget compiles a vellum scene or a vellumplot plot into a self-contained client-side htmlwidget with hover, select, brush, lasso, pan/zoom and export, and no server round-trip. The two-way Shiny story is complete: interactions surface as reactive inputs keyed by output id, and vellumwidget_proxy() drives an already-rendered widget from the server without re-rendering it. The last two releases are fidelity work rather than new surface, calibrating hit-testing from the rendered positions of marks and rendering the raster base image at 2x for HiDPI screens.
glyenzy vs vellumwidget: editorial side-by-side
glyenzy
6.3ANALYTICS
Glycan biosynthesis as a traceable enzyme graph, now including sulfation and gaps it can bridge.
◆ Current state
glyenzy infers which enzymes could have produced a glycan and traces biosynthetic routes to it, backed by curated per-enzyme rules for human glycosyltransferases and, since 0.7.0, twelve sulfotransferases. Biosynthesis functions return typed network objects that keep their igraph interface while supporting layered DAG plots with glycan nodes and labelled enzyme edges. Where no concrete enzyme covers a step, bounded virtual transitions bridge the gap and are marked so users can see which edges are inferred rather than enzymatic.
◆ Where it's heading
Two kinds of release alternate here. One is enzyme curation, a steady stream of rule corrections for the FUT, MAN1A and MGAT families and removals where an enzyme turned out to act only on glycolipids, which is the unglamorous accuracy work a rule-based inference engine lives on. The other is turning biosynthesis output into a first-class object: paths became networks, networks became typed with plotting support, and targets became a marked vertex attribute. The package moves in lockstep with its siblings, pinning glyrepr 0.13.0 and glymotif 0.17.0 as those refreshed their data and matching APIs, and the latest release already speaks glydraw 0.8.0's orientation values.
◆ Prediction
The paucimannose N-glycan support dropped in 0.7.0 is the obvious loose end, with users told to stay on 0.6.3, so a reinstated implementation is a plausible next move. Beyond that the virtual-step machinery is new enough that its heuristics, particularly the inferred step limits added in 0.8.1, should keep being tuned.
vellumwidget
6.3ANALYTICS
vellumwidget is dissolving its own API: interaction now lives in the plot spec, not the widget call.
◆ Current state
vellumwidget compiles a vellum scene or a vellumplot plot into a self-contained client-side htmlwidget with hover, select, brush, lasso, pan/zoom and export, and no server round-trip. The two-way Shiny story is complete: interactions surface as reactive inputs keyed by output id, and vellumwidget_proxy() drives an already-rendered widget from the server without re-rendering it. The last two releases are fidelity work rather than new surface, calibrating hit-testing from the rendered positions of marks and rendering the raster base image at 2x for HiDPI screens.
◆ Where it's heading
The direction is declarative. 0.7.0 removed the interaction-intent arguments from as_widget() outright, dropping the signature from roughly 36 arguments to 24 and moving highlight, filter and cross-filter into vellumplot's spec via select_point(), condition() and filter_by(). Each release since has enacted more of that compiled spec on the frozen scene, from conditional encodings to single-view filters to cross-view cross-filtering, leaving the widget as an interpreter of the plot rather than a configuration surface of its own. The bug fixes track the same theme the engine's do: measured geometry and rendered geometry must not drift.
◆ Prediction
The notes name the remaining hold-outs explicitly, saying hover_mode, crosshair, legend_click, select_mode and the tooltip-appearance arguments remain only until their spec equivalents land, so the next releases most likely move those into vellumplot and shrink as_widget() further. The scale binds flagged as following the filter work are the other stated next step.
Alternatives to glyenzy and vellumwidget
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either glyenzy or vellumwidget.
glydet
glydet is rebuilding its glycan trait vocabulary on top of someone else's container.
glyexp
glyexp is retiring its own data container and handing the job to Bioconductor.
glymotif
A glycan motif matcher trading convenience wrappers for speed, strictness and explicit specs.
glyrepr
The type system the rest of the glycan stack is built on, being hardened one breaking change at a time.
glyanno
Glycan annotation stops depending on the database having seen the structure before.
See all glyenzy alternatives → · See all vellumwidget alternatives →
Recent activity from glyenzy and vellumwidget
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 14d agoglyenzyStep limits inferred from the target glycan; MGAT4 and MGAT5 rules updated
- 14d agovellumwidget2x raster base image for HiDPI, and exact element hit-testing
- 17d agoglyenzyBiosynthesis results become typed network objects with layered DAG plots
- 20d agovellumwidgetInteraction moves into the plot spec; as_widget() sheds a third of its arguments ⚡
- 23d agoglyenzySulfotransferases become first-class, and unsupported steps can be bridged ⚡
- 27d agovellumwidgetAxis-aware zoom re-ticks the axes instead of scaling the whole scene
- 1mo agovellumwidgetSelectable native SVG text, and crisp canvas redraw when zooming raster
- 1mo agovellumwidgetServer-side proxy drives a rendered widget without re-rendering it
- 1mo agovellumwidgetShiny input read-back, and keyboard plus screen-reader access by default
- 1mo agoglyenzyCompatibility with glymotif 0.17.0 and later
- 1mo agoglyenzyEnzyme data refreshed against glyrepr 0.13.0 structure data
- 1mo agoglyenzyCorrected rules for the MAN1A1, MAN1A2 and MAN1C1 mannosidases
Frequently asked questions
What is the difference between glyenzy and vellumwidget?
They serve adjacent needs but don't currently overlap on shipped themes. glyenzy and vellumwidget are shipping at a similar cadence (velocity 6.3 vs 6.3, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is glyenzy better than vellumwidget?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. glyenzy and vellumwidget are shipping at a similar cadence (velocity 6.3 vs 6.3, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to glyenzy?
Top glyenzy alternatives in Analytics are ranked by recent ship velocity. Browse the "glyenzy alternatives" section above for the current picks, or visit /alternatives/glyenzy for the full list with editorial commentary on each.
What are the best alternatives to vellumwidget?
Top vellumwidget alternatives in Analytics are ranked by recent ship velocity. Browse the "vellumwidget alternatives" section above for the current picks, or visit /alternatives/vellumwidget for the full list with editorial commentary on each.