STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
GeneNMF vs regfusionr
A side-by-side editorial comparison of GeneNMF and regfusionr — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
GeneNMF vs regfusionr: at a glance
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
What is regfusionr?
Registration fusion mapping goes bidirectional, and a vertex-indexing bug that silently returned wrong coordinates is fixed
regfusionr maps coordinates between volumetric brain templates (MNI152, Colin27) and the fsaverage surface. After four dormant years it returned in July 2026 with a release that fixes a coordinate-indexing bug, unblocks a previously disabled function, and completes the template-by-method matrix so all four combinations answer point queries. It also breaks compatibility by switching to the standard FREESURFER_HOME environment variable.
GeneNMF vs regfusionr: editorial side-by-side
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
regfusionr
3.8ANALYTICS
Registration fusion mapping goes bidirectional, and a vertex-indexing bug that silently returned wrong coordinates is fixed
◆ Current state
regfusionr maps coordinates between volumetric brain templates (MNI152, Colin27) and the fsaverage surface. After four dormant years it returned in July 2026 with a release that fixes a coordinate-indexing bug, unblocks a previously disabled function, and completes the template-by-method matrix so all four combinations answer point queries. It also breaks compatibility by switching to the standard FREESURFER_HOME environment variable.
◆ Where it's heading
The package moved from a partial implementation to a complete one in a single release. Before this, vol_coords_to_fsaverage returned coordinates indexed by query position rather than by vertex index — results that looked plausible and were wrong — and fsaverage_to_vol was guarded behind a stop(). Both are now resolved, and the new Colin27 and MNI152 convenience functions make the mapping bidirectional. The sibling package haze shipped a maintenance release 56 minutes later, marking this as a coordinated sweep across the maintainer's neuroimaging stack.
◆ Prediction
With the four template-by-method combinations closed and the coordinate bug fixed, the next release is more likely to be CRAN-adjacent packaging or documentation than new mapping capability.
Alternatives to GeneNMF and regfusionr
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either GeneNMF or regfusionr.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all GeneNMF alternatives → · See all regfusionr alternatives →
Recent activity from GeneNMF and regfusionr
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 18d agoregfusionrVersion 0.3.0 -- vol_to_fsaverage, many convenience functions and fixes ⚡
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
- 4y agoregfusionrv0.2.0 -- surface to volume data projection
- 4y agoregfusionrv0.1.0: Initial release
Frequently asked questions
What is the difference between GeneNMF and regfusionr?
Both compete on the same themes — r-package — within Analytics. regfusionr is currently shipping more aggressively (velocity 3.8 vs 0.0), with 1 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is GeneNMF better than regfusionr?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. regfusionr is currently shipping more aggressively (velocity 3.8 vs 0.0), with 1 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.
What are the best alternatives to regfusionr?
Top regfusionr alternatives in Analytics are ranked by recent ship velocity. Browse the "regfusionr alternatives" section above for the current picks, or visit /alternatives/regfusionr for the full list with editorial commentary on each.