STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
GeneNMF vs qtl2fst
A side-by-side editorial comparison of GeneNMF and qtl2fst — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
GeneNMF vs qtl2fst: at a glance
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
What is qtl2fst?
The out-of-memory backend for R/qtl2, feature-complete since 2020 and now purely on upkeep
qtl2fst backs R/qtl2 genotype probabilities with on-disk fst files so large crosses don't have to fit in RAM. Its defining release was 0.22 in 2020, which added calc_genoprob_fst() and genoprob_to_alleleprob_fst() to fuse calculation and storage in one step. The five releases since are documentation links, directory-creation robustness, a Windows example fix, and — in 0.32 — a change to how cores=0 is interpreted.
GeneNMF vs qtl2fst: editorial side-by-side
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
qtl2fst
0.0ANALYTICS
The out-of-memory backend for R/qtl2, feature-complete since 2020 and now purely on upkeep
◆ Current state
qtl2fst backs R/qtl2 genotype probabilities with on-disk fst files so large crosses don't have to fit in RAM. Its defining release was 0.22 in 2020, which added calc_genoprob_fst() and genoprob_to_alleleprob_fst() to fuse calculation and storage in one step. The five releases since are documentation links, directory-creation robustness, a Windows example fix, and — in 0.32 — a change to how cores=0 is interpreted.
◆ Where it's heading
The package has settled into the role of a stable satellite of R/qtl2: it tracks the parent package's conventions rather than setting its own. The cores=0 change in 0.32 arrived alongside the identical change in qtl2convert, so the parallel-computing default is being standardized across the maintainer's packages at once. Release intervals have stretched from months to years.
◆ Prediction
Further releases will most likely mirror changes originating in R/qtl2 or CRAN checks, in the same follow-the-parent pattern as 0.24 and 0.32.
Alternatives to GeneNMF and qtl2fst
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either GeneNMF or qtl2fst.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all GeneNMF alternatives → · See all qtl2fst alternatives →
Recent activity from GeneNMF and qtl2fst
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 1mo agoqtl2fstcores=0 now leaves one core free instead of taking all
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoqtl2fstWindows fix for the replace_path() example
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoqtl2fstDocumentation link fix
- 2y agoGeneNMFFirst stable release published to CRAN
- 4y agoqtl2fstCreates missing directories instead of erroring out
- 5y agoqtl2fstTest coverage for qtl2 functions against fst-backed probabilities
- 6y agoqtl2fstDocumentation and metadata cleanup for CRAN
Frequently asked questions
What is the difference between GeneNMF and qtl2fst?
Both compete on the same themes — r-package — within Analytics. GeneNMF and qtl2fst are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is GeneNMF better than qtl2fst?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. GeneNMF and qtl2fst are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.
What are the best alternatives to qtl2fst?
Top qtl2fst alternatives in Analytics are ranked by recent ship velocity. Browse the "qtl2fst alternatives" section above for the current picks, or visit /alternatives/qtl2fst for the full list with editorial commentary on each.