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Comparison · Analytics

forrel vs GeneNMF

A side-by-side editorial comparison of forrel and GeneNMF — release velocity, themes, recent moves, and the top alternatives to consider.

forrel vs GeneNMF: at a glance

FeatureforrelGeneNMF
SectorAnalyticsAnalytics
Velocity score0.00.0
Sparks · 30d00
Top themesforensic genetics, kinship analysis, simulation, parallel computingsingle-cell-genomics, nmf, gene-programs, bioinformatics
Last editorial update1d ago49m ago
WebsiteVisit →Visit →

What is forrel?

forrel is getting faster at the simulations forensic kinship work actually spends its time on.

forrel handles forensic pedigree analysis: kinship likelihood ratios, profile simulation, relationship checking, and missing person calculations. Version 1.9.0 synced with pedtools 2.11.0's loop handling, which the release notes credit with enabling complex pedigrees that were previously intractable, and moved profileSim() to mirai for parallelism. It also added fEstimate() for inbreeding coefficients and parentChildLikelihood() as a fast path for the simplest case.

Read the full forrel trajectory →

What is GeneNMF?

GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.

GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.

Read the full GeneNMF trajectory →

forrel vs GeneNMF: editorial side-by-side

F
forrel
ANALYTICS
0.0

forrel is getting faster at the simulations forensic kinship work actually spends its time on.

◆ Current state

forrel handles forensic pedigree analysis: kinship likelihood ratios, profile simulation, relationship checking, and missing person calculations. Version 1.9.0 synced with pedtools 2.11.0's loop handling, which the release notes credit with enabling complex pedigrees that were previously intractable, and moved profileSim() to mirai for parallelism. It also added fEstimate() for inbreeding coefficients and parentChildLikelihood() as a fast path for the simplest case.

◆ Where it's heading

Two long threads run through the window. One is making the common operations cheap: faster simulations through reorganized likelihood calculations, a dedicated parent-child path, dropped map attribute preservation, log-likelihoods to avoid underflow in kinshipLR(). The other is making relationship checking presentable, with checkPairwise() growing ggplot2 and plotly output, verbal relationship descriptions, and bootstrap p-values. Reference data is maintained alongside both, with the FORCE SNP panel completed and an X-chromosomal counterpart added.

◆ Prediction

With profileSim() on mirai and the loop handling synced, the next likely step is extending mirai parallelism to the other simulation-heavy functions such as exclusionPower() and the bootstrap in checkPairwise().

G
GeneNMF
ANALYTICS
0.0

GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.

◆ Current state

GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.

◆ Where it's heading

The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.

◆ Prediction

Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.

Alternatives to forrel and GeneNMF

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either forrel or GeneNMF.

See all forrel alternatives → · See all GeneNMF alternatives →

Recent activity from forrel and GeneNMF

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 1mo agoforrelmirai parallelism and faster profile simulation
  2. 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
  3. 1y agoforrelFORCE SNP panel completed and X-chromosomal set added
  4. 1y agoforrelrankProfiles() and access to special lumping
  5. 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
  6. 1y agoforrelacrossComps argument and readFam() unexported
  7. 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
  8. 1y agoforrelcheckPairwise() overhauled with p-values and new plot backends
  9. 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity
  10. 2y agoGeneNMFFirst stable release published to CRAN
  11. 2y agoforrelFamilias interoperability split into pedFamilias

Frequently asked questions

What is the difference between forrel and GeneNMF?

They serve adjacent needs but don't currently overlap on shipped themes. forrel and GeneNMF are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is forrel better than GeneNMF?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. forrel and GeneNMF are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to forrel?

Top forrel alternatives in Analytics are ranked by recent ship velocity. Browse the "forrel alternatives" section above for the current picks, or visit /alternatives/forrel for the full list with editorial commentary on each.

What are the best alternatives to GeneNMF?

Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.