STACAS
Single-cell batch correction that learned to use cell labels, then spent three releases chasing Seurat.
Comparison · Analytics
e2tree vs GeneNMF
A side-by-side editorial comparison of e2tree and GeneNMF — release velocity, themes, recent moves, and the top alternatives to consider.
Shared themes:r-package
e2tree vs GeneNMF: at a glance
What is e2tree?
The explainable-ensemble-tree package now measures whether its own explanations are faithful.
e2tree builds a single interpretable tree that approximates a fitted ensemble, working from the proximity structure the ensemble induces between observations. The 1.0.0 release added the piece that had been missing: a Goodness of Interpretability index quantifying how well the approximating tree reconstructs the ensemble's own proximity matrix, with a permutation test for significance. Interactive visualisation and a C++ backend with OpenMP parallelism arrived alongside, and support now spans ranger and CatBoost as well as the original targets.
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
e2tree vs GeneNMF: editorial side-by-side
e2tree
0.0ANALYTICS
The explainable-ensemble-tree package now measures whether its own explanations are faithful.
◆ Current state
e2tree builds a single interpretable tree that approximates a fitted ensemble, working from the proximity structure the ensemble induces between observations. The 1.0.0 release added the piece that had been missing: a Goodness of Interpretability index quantifying how well the approximating tree reconstructs the ensemble's own proximity matrix, with a permutation test for significance. Interactive visualisation and a C++ backend with OpenMP parallelism arrived alongside, and support now spans ranger and CatBoost as well as the original targets.
◆ Where it's heading
Development has moved from producing an explanation to defending it. The GoI index and its permutation test change the package's claim from here is a tree that resembles your ensemble to here is how closely it resembles it and whether that could have happened by chance — the question a reviewer asks of any surrogate model. Around that, the work is engineering: the proximity matrix construction moved from R-level parallel loops into C++ with thread-level parallelism, and recent releases have been absorbing the awkwardness of supporting multiple ensemble backends, where a multi-class CatBoost objective returns a score matrix where a vector was expected. Interactive visNetwork output and standalone HTML export point at explanations meant to be shared rather than only inspected.
◆ Prediction
Given how much recent effort has gone into per-backend adapters, expect further work on ensemble compatibility; the entries do not indicate whether the interpretability index is heading toward comparing surrogate trees against each other.
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
Alternatives to e2tree and GeneNMF
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either e2tree or GeneNMF.
ggtrace
A debugger for ggplot2's internals, hardening its grip as the internals it traces keep moving.
kde1d
A univariate density estimator that added zero-inflated data and reopened its C++ API to do it.
svines
Stationary vine copulas for time series, released in lockstep with the rest of Nagler's vine stack.
gghighlight
A single-purpose ggplot2 extension that has spent six years tracking ggplot2 instead of growing.
rtrek
A Star Trek data package that became a Memory Alpha web client and has been patching scrapers ever since.
See all e2tree alternatives → · See all GeneNMF alternatives →
Recent activity from e2tree and GeneNMF
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 3mo agoe2treeCatBoost multi-class and loss-function handling repaired
- 4mo agoe2treeA significance-tested measure of explanation fidelity ⚡
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoe2treeranger models supported
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
Frequently asked questions
What is the difference between e2tree and GeneNMF?
Both compete on the same themes — r-package — within Analytics. e2tree and GeneNMF are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is e2tree better than GeneNMF?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. e2tree and GeneNMF are shipping at a similar cadence (velocity 0.0 vs 0.0, both within Sparkpulse's "active" band). For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to e2tree?
Top e2tree alternatives in Analytics are ranked by recent ship velocity. Browse the "e2tree alternatives" section above for the current picks, or visit /alternatives/e2tree for the full list with editorial commentary on each.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.