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Comparison · Analytics

DoseFinding vs xplainfi

A side-by-side editorial comparison of DoseFinding and xplainfi — release velocity, themes, recent moves, and the top alternatives to consider.

DoseFinding vs xplainfi: at a glance

FeatureDoseFindingxplainfi
SectorAnalyticsAnalytics
Velocity score0.02.5
Sparks · 30d00
Top themesdose-response, mcp-mod, clinical-trials, model-averagingmlr3, feature-importance, interpretability, statistical-inference
Last editorial update1h ago7h ago
WebsiteVisit →Visit →

What is DoseFinding?

New stewardship at openpharma, then two releases adding the methods MCP-Mod was missing

DoseFinding implements MCP-Mod and related dose-response methodology for clinical trial design and analysis. In 2024 it changed hands — Marius Thomas took over as maintainer, Novartis was recorded as copyright holder and funder, and the package moved to the openpharma GitHub organisation with roxygen documentation and a proper NEWS file. The two releases since have added substantive methodology: model averaging for dose-response fitting in 1.3-1, and conditional and predictive power for interim analyses in 1.4-1.

Read the full DoseFinding trajectory →

What is xplainfi?

xplainfi treats feature importance as an estimate with error bars, not a number.

xplainfi implements feature importance methods for mlr3 — perturbation-based PFI, CFI and RFI, refit-based LOCO and WVIM, and SAGE. Its defining choice is that importance scores come with inference attached: several confidence-interval methods, including the Nadeau-Bengio correction and a distribution-free option added in 1.1.0. It declared itself released at 1.0.0 in January 2026.

Read the full xplainfi trajectory →

DoseFinding vs xplainfi: editorial side-by-side

D
DoseFinding
ANALYTICS
0.0

New stewardship at openpharma, then two releases adding the methods MCP-Mod was missing

◆ Current state

DoseFinding implements MCP-Mod and related dose-response methodology for clinical trial design and analysis. In 2024 it changed hands — Marius Thomas took over as maintainer, Novartis was recorded as copyright holder and funder, and the package moved to the openpharma GitHub organisation with roxygen documentation and a proper NEWS file. The two releases since have added substantive methodology: model averaging for dose-response fitting in 1.3-1, and conditional and predictive power for interim analyses in 1.4-1.

◆ Where it's heading

The pattern before the handover was maintenance — R-devel compliance, a bug fix, a link. After it, each release carries a named methodological addition with an acknowledged contributor, plus documentation to match: a longitudinal analysis vignette shipped alongside the interim power work. Housekeeping continues underneath, mostly clearing deprecated ggplot2 interfaces, aes_string in one release and qplot in the next.

◆ Prediction

Given the last two releases each added one method with a supporting vignette, expect the next to follow the same shape. Both additions so far extend the package beyond fixed dose-response fitting, so adaptive and interim methodology is the more likely direction.

X
xplainfi
ANALYTICS
2.5

xplainfi treats feature importance as an estimate with error bars, not a number.

◆ Current state

xplainfi implements feature importance methods for mlr3 — perturbation-based PFI, CFI and RFI, refit-based LOCO and WVIM, and SAGE. Its defining choice is that importance scores come with inference attached: several confidence-interval methods, including the Nadeau-Bengio correction and a distribution-free option added in 1.1.0. It declared itself released at 1.0.0 in January 2026.

◆ Where it's heading

Two lines of work run in parallel. The statistical side keeps adding inference options — variance corrections, conditional predictive impact, and the Lei et al. observation-wise loss-difference test — while the computational side attacks the cost of refit-based methods, most recently with a batch_size argument that parallelises refits and a default of one refit per resampling iteration. Support for pre-trained learners in 1.1.0 removes the refit requirement entirely in some workflows.

◆ Prediction

The stated reasoning that budget is better spent on resampling iterations than repeated refits suggests n_repeats may be removed from WVIM and LOCO outright, as the release notes hint.

Alternatives to DoseFinding and xplainfi

Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either DoseFinding or xplainfi.

See all DoseFinding alternatives → · See all xplainfi alternatives →

Recent activity from DoseFinding and xplainfi

Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.

  1. 21d agoxplainfiRefits parallelise; repeated refits deprioritised in favour of resampling
  2. 5mo agoxplainfiPre-trained learners supported; distribution-free inference added
  3. 6mo agoxplainfiVersion bumped to mark the package as released
  4. 9mo agoxplainfiConfidence intervals arrive for feature importance scores
  5. 1y agoDoseFindingConditional and predictive power for interim analyses
  6. 1y agoDoseFindingModel averaging arrives for dose-response fitting
  7. 1y agoDoseFindingPackage moves to openpharma under new maintainership
  8. 2y agoDoseFindingCompliance update for R-devel
  9. 3y agoDoseFindingpowMCTBinCount bug fix

Frequently asked questions

What is the difference between DoseFinding and xplainfi?

They serve adjacent needs but don't currently overlap on shipped themes. xplainfi is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.

Is DoseFinding better than xplainfi?

Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. xplainfi is currently shipping more aggressively (velocity 2.5 vs 0.0), with 0 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.

What are the best alternatives to DoseFinding?

Top DoseFinding alternatives in Analytics are ranked by recent ship velocity. Browse the "DoseFinding alternatives" section above for the current picks, or visit /alternatives/dosefinding for the full list with editorial commentary on each.

What are the best alternatives to xplainfi?

Top xplainfi alternatives in Analytics are ranked by recent ship velocity. Browse the "xplainfi alternatives" section above for the current picks, or visit /alternatives/xplainfi for the full list with editorial commentary on each.